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COPS5 and BRSK2
Data Source:
BioGRID
(pull down, affinity chromatography technology)
COPS5
BRSK2
Description
COP9 signalosome subunit 5
BR serine/threonine kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Synaptic Vesicle
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Endoplasmic Reticulum
Centrosome
Perinuclear Region Of Cytoplasm
Distal Axon
Molecular Function
Transcription Coactivator Activity
Translation Initiation Factor Activity
Metalloendopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
NEDD8-specific Protease Activity
Enzyme Binding
Macrophage Migration Inhibitory Factor Binding
Metal Ion Binding
Isopeptidase Activity
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
ATP Binding
Protein Kinase Binding
Tau Protein Binding
Tau-protein Kinase Activity
ATPase Binding
ATPase Regulator Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Translation
Translational Initiation
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of IRE1-mediated Unfolded Protein Response
Exosomal Secretion
G2/M Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Exocytosis
Axonogenesis
Regulation Of Neuron Projection Development
Peptidyl-serine Phosphorylation
Establishment Of Cell Polarity
Neuron Differentiation
Actin Cytoskeleton Reorganization
Intracellular Signal Transduction
ERAD Pathway
Cellular Response To Glucose Starvation
Regulation Of ATPase Activity
Regulation Of Axonogenesis
Cell Division
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity
Regulation Of Retrograde Protein Transport, ER To Cytosol
Regulation Of Synaptic Vesicle Clustering
Pathways
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Gout (
32238385
)
Heroin dependence (
27936112
)
Idiopathic pulmonary fibrosis (
24429156
)
Interacting Genes
98 interacting genes:
APCS
ARFGAP1
ATM
ATRN
BCL2L14
BCL3
BRD4
BRSK2
CACNA1C
CD274
CD93
CDKN1B
CENPT
CHUK
COPS2
COPS3
COPS4
COPS6
COPS7A
COPS7B
COPS8
COPS9
CUL1
CUL2
CUL3
CUL4A
CUL5
DDB1
DDO
ERN1
ERRFI1
ESR1
F2RL1
GFER
GFI1B
GPS1
GTPBP3
HAND2
HIF1A
HNF4A
HNF4G
HTR6
ITGB2
JUN
JUND
LASP1
MAP2K2
MAP3K11
MAP3K3
MAP3K7
MAP4K3
MAP4K5
MAPK14
MAPRE1
MAX
MDC1
MDM2
MEF2C
MEF2D
MIF
MTRES1
MYG1
NCOA1
NEDD8
NFKB1
NR4A2
NR4A3
OPRM1
PEA15
PGR
PLAC8
PPARG
PPOX
PPP1CC
PRDX2
PRKD1
PTGS2
RAD1
RAD9A
RNF139
RORA
S100A7
SHANK3
SHISA5
SMAD2
SMAD4
SMAD5
SPP1
SREBF2
TOP2A
TP53
TXN
TYK2
UCHL1
USP14
VTN
WNK1
YWHAG
7 interacting genes:
CDC25B
CDC25C
COPS5
MAPT
TRAF6
VCP
WEE1
Entrez ID
10987
9024
HPRD ID
06888
11611
Ensembl ID
ENSG00000121022
ENSG00000174672
Uniprot IDs
A0A024R7W9
Q92905
A0A024RCE9
A0A140VJF6
B4DLY3
Q8IWQ3
PDB IDs
4D10
4D18
4F7O
4WSN
5JOG
5JOH
5M5Q
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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