ITIH2 and SPINT2

Data Source:
BioGRID (pull down)

		ITIH2	SPINT2
Description		inter-alpha-trypsin inhibitor heavy chain 2	serine peptidase inhibitor, Kunitz type 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	MET Receptor Activation Signaling by MST1
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 29875488) Ovarian reserve ( 22116950)	Blood protein levels ( 30072576 29875488) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: ATP5F1C FCER1A SPINT2	6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4
Entrez ID		3698	10653
HPRD ID		00890	05495
Ensembl ID		ENSG00000151655	ENSG00000167642
Uniprot IDs		P19823	A0A140VJV6 O43291
PDB IDs			4U32
Enriched GO Terms of Interacting Partners?
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