SPINT2 and ITIH2

Data Source:
BioGRID (pull down)

		SPINT2	ITIH2
Description		serine peptidase inhibitor, Kunitz type 2	inter-alpha-trypsin inhibitor heavy chain 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		MET Receptor Activation Signaling by MST1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494)	Blood protein levels ( 29875488) Ovarian reserve ( 22116950)
Interacting Genes		6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	3 interacting genes: ATP5F1C FCER1A SPINT2
Entrez ID		10653	3698
HPRD ID		05495	00890
Ensembl ID		ENSG00000167642	ENSG00000151655
Uniprot IDs		A0A140VJV6 O43291	P19823
PDB IDs		4U32
Enriched GO Terms of Interacting Partners?
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