SPINT2 and ITIH3

Data Source:
HPRD (in vivo)

		SPINT2	ITIH3
Description		serine peptidase inhibitor, Kunitz type 2	inter-alpha-trypsin inhibitor heavy chain 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation	Platelet Degranulation Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process
Pathways		MET Receptor Activation Signaling by MST1	Platelet degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 31043756) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-2) ( 22610502) Parkinson's disease ( 28892059) Red blood cell count ( 32888494 27863252) Schizophrenia ( 25056061 21926974 29483656 30285260 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	2 interacting genes: EP300 SPINT2
Entrez ID		10653	3699
HPRD ID		05495	00891
Ensembl ID		ENSG00000167642	ENSG00000162267
Uniprot IDs		A0A140VJV6 O43291	Q06033
PDB IDs		4U32
Enriched GO Terms of Interacting Partners?
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