ITIH2 and FCER1A

Data Source:
HPRD (in vitro)

		ITIH2	FCER1A
Description		inter-alpha-trypsin inhibitor heavy chain 2	Fc fragment of IgE receptor Ia
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Transmembrane Signaling Receptor Activity Protein Binding IgE Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune Response
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Omalizumab Benzylpenicilloyl polylysine TNX-901
Diseases
GWAS		Blood protein levels ( 29875488) Ovarian reserve ( 22116950)	C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)
Interacting Genes		3 interacting genes: ATP5F1C FCER1A SPINT2	6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB
Entrez ID		3698	2205
HPRD ID		00890	00917
Ensembl ID		ENSG00000151655	ENSG00000179639
Uniprot IDs		P19823	P12319
PDB IDs			1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?
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