SPINT2 and SUMO4

Data Source:
HPRD (in vivo)

		SPINT2	SUMO4
Description		serine peptidase inhibitor, Kunitz type 2	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane	Nucleus SUMO Ligase Complex
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494)	Dupuytren's disease ( 28886342)
Interacting Genes		6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		10653	387082
HPRD ID		05495	10584
Ensembl ID		ENSG00000167642	ENSG00000177688
Uniprot IDs		A0A140VJV6 O43291	Q6EEV6
PDB IDs		4U32
Enriched GO Terms of Interacting Partners?
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