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ITGAM and SCN3B
Data Source:
BioGRID
(two hybrid)
ITGAM
SCN3B
Description
integrin subunit alpha M
sodium voltage-gated channel beta subunit 3
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Integrin AlphaM-beta2 Complex
Specific Granule Membrane
Plasma Membrane Raft
Extracellular Exosome
Tertiary Granule Membrane
Voltage-gated Sodium Channel Complex
Plasma Membrane
Integral Component Of Membrane
Z Disc
Molecular Function
Amyloid-beta Binding
Complement Component C3b Binding
Integrin Binding
Protein Binding
Heat Shock Protein Binding
Cargo Receptor Activity
Metal Ion Binding
Voltage-gated Ion Channel Activity
Protein Binding
Sodium Channel Regulator Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
Biological Process
Microglial Cell Activation
Receptor-mediated Endocytosis
Phagocytosis, Engulfment
Cell Adhesion
Integrin-mediated Signaling Pathway
Ectodermal Cell Differentiation
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Forebrain Development
Positive Regulation Of Superoxide Anion Generation
Toll-like Receptor 4 Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of Neutrophil Degranulation
Innate Immune Response
Negative Regulation Of Dopamine Metabolic Process
Leukocyte Migration
Positive Regulation Of Protein Targeting To Membrane
Apoptotic Signaling Pathway
Amyloid-beta Clearance
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Hippocampal Neuron Apoptotic Process
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Positive Regulation Of Neuron Death
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Positive Regulation Of Prostaglandin-E Synthase Activity
Sodium Ion Transport
Nervous System Development
Positive Regulation Of Heart Rate
Positive Regulation Of Sodium Ion Transport
Sensory Perception Of Pain
Sodium Ion Transmembrane Transport
Membrane Depolarization
Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Membrane Depolarization During Cardiac Muscle Cell Action Potential
Atrial Cardiac Muscle Cell Action Potential
SA Node Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Interaction between L1 and Ankyrins
Phase 0 - rapid depolarisation
Drugs
Ranolazine
Valproic acid
Oxcarbazepine
Cocaine
Zonisamide
Brivaracetam
Dichlorobenzyl alcohol
Fish oil
Diseases
Brugada syndrome (BRS)
GWAS
Apolipoprotein A1 levels (
32203549
)
Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) (
22922229
)
Graves' disease (
22922229
)
IgA nephropathy (
25305756
)
Serum metabolite levels (CMS) (
31636271
)
Systemic lupus erythematosus (
27399966
18204446
24871463
26606652
23273568
26502338
18204098
21408207
19165918
28714469
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Chronic lymphocytic leukemia (
28165464
24292274
23770605
)
Response to citalopram or escitalopram in depression (
27622933
)
Interacting Genes
55 interacting genes:
ABHD16A
AQP6
ARL13B
AUP1
C3
CD209
CD79A
CERS4
CFH
CLEC4M
CLRN1
CREB3L1
DKK4
ELANE
ELOVL4
ERGIC3
FGG
GJA8
GJB1
GORAB
GP1BA
GPR42
HP
HSD17B13
ICAM1
ICAM2
ICAM4
IRAK1
ITGB2
JAM3
KASH5
KCNJ6
KIR2DL3
LMNA
MGST3
MMGT1
MRM1
MUC1
PGRMC2
PIGP
PLAUR
REEP2
REEP4
RUSF1
SCN3B
SHARPIN
SLC10A6
SLC35C2
SYT2
THY1
TMEM14B
TMEM229B
TMEM31
TMEM52B
TMX2
105 interacting genes:
ADIPOQ
AGPAT4
AGPAT5
ANKRD46
AQP10
ARV1
ATP13A1
ATP6V0C
BNIP1
BNIP3
BRICD5
CLCA4
CTXN3
CYP4F2
DEFB103A
DEFB103B
DERL1
DGAT2L6
ERG28
FAM241B
FAM3C
FIS1
FKBP8
FXYD3
GIMAP1
GIMAP5
GPR151
GPR61
IER3IP1
INSIG2
ISM2
ITGAM
LEMD1
LEPROTL1
LPAR3
MAL2
MARCHF2
MFSD5
MGST3
MS4A13
NFASC
NINJ2
ORMDL1
ORMDL2
PLBD2
PLP2
PLPPR2
PMP22
RHD
RNF8
RUSF1
SACM1L
SCD
SEC22A
SERP2
SFT2D1
SFXN1
SFXN3
SLC2A5
SLC30A3
SLC30A8
SLC35A4
SLC35E4
SLC38A1
SLC38A7
SLC7A1
SMCO4
SMIM1
STRIT1
STX3
STX6
STX8
THSD7A
TIMM23
TM6SF2
TMBIM6
TMEM120A
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM208
TMEM239
TMEM243
TMEM42
TMEM50B
TMEM60
TMEM65
TMEM86A
TMPPE
TPRG1
TRARG1
TSPAN2
TVP23B
UBIAD1
USE1
VAMP1
VAMP2
VAMP3
VAPA
VAPB
YIF1A
YIPF4
ZFPL1
Entrez ID
3684
55800
HPRD ID
00411
10497
Ensembl ID
ENSG00000169896
ENSG00000166257
Uniprot IDs
P11215
A0A024R3H7
Q9NY72
PDB IDs
1A8X
1BHO
1BHQ
1IDN
1IDO
1JLM
1M1U
1MF7
1N9Z
1NA5
2LKE
2LKJ
3Q3G
3QA3
4M76
4XW2
6RHW
4L1D
Enriched GO Terms of Interacting Partners
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