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ITGAM and GPR42
Data Source:
BioGRID
(two hybrid)
ITGAM
GPR42
Description
integrin subunit alpha M
G protein-coupled receptor 42
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Integrin AlphaM-beta2 Complex
Specific Granule Membrane
Plasma Membrane Raft
Extracellular Exosome
Tertiary Granule Membrane
Integral Component Of Plasma Membrane
Molecular Function
Amyloid-beta Binding
Complement Component C3b Binding
Integrin Binding
Protein Binding
Heat Shock Protein Binding
Cargo Receptor Activity
Metal Ion Binding
G Protein-coupled Receptor Activity
Protein Binding
Biological Process
Microglial Cell Activation
Receptor-mediated Endocytosis
Phagocytosis, Engulfment
Cell Adhesion
Integrin-mediated Signaling Pathway
Ectodermal Cell Differentiation
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Forebrain Development
Positive Regulation Of Superoxide Anion Generation
Toll-like Receptor 4 Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of Neutrophil Degranulation
Innate Immune Response
Negative Regulation Of Dopamine Metabolic Process
Leukocyte Migration
Positive Regulation Of Protein Targeting To Membrane
Apoptotic Signaling Pathway
Amyloid-beta Clearance
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Hippocampal Neuron Apoptotic Process
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Positive Regulation Of Neuron Death
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Positive Regulation Of Prostaglandin-E Synthase Activity
G Protein-coupled Receptor Signaling Pathway
Pathways
Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) (
22922229
)
Graves' disease (
22922229
)
IgA nephropathy (
25305756
)
Serum metabolite levels (CMS) (
31636271
)
Systemic lupus erythematosus (
27399966
18204446
24871463
26606652
23273568
26502338
18204098
21408207
19165918
28714469
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Interacting Genes
55 interacting genes:
ABHD16A
AQP6
ARL13B
AUP1
C3
CD209
CD79A
CERS4
CFH
CLEC4M
CLRN1
CREB3L1
DKK4
ELANE
ELOVL4
ERGIC3
FGG
GJA8
GJB1
GORAB
GP1BA
GPR42
HP
HSD17B13
ICAM1
ICAM2
ICAM4
IRAK1
ITGB2
JAM3
KASH5
KCNJ6
KIR2DL3
LMNA
MGST3
MMGT1
MRM1
MUC1
PGRMC2
PIGP
PLAUR
REEP2
REEP4
RUSF1
SCN3B
SHARPIN
SLC10A6
SLC35C2
SYT2
THY1
TMEM14B
TMEM229B
TMEM31
TMEM52B
TMX2
104 interacting genes:
ADIPOQ
ALOX5AP
ANKRD46
APOD
ATP13A1
ATP4B
ATP6V0B
ATP6V0C
BNIP3
BTN2A2
C1GALT1
CCDC167
CCL4L2
CD300C
CD79A
CLCA4
CLEC2D
COMT
CTXN3
CXCL16
CXCL9
DRAM1
EFNA5
EMP1
ERMP1
FAM3C
FXYD3
FXYD6
GJB2
GOSR2
GPR37L1
GYPC
IER3IP1
IGFBP5
IL1RL1
ITGAM
JPH1
KCNA1
KLRG1
LAT
LEPROTL1
LHFPL5
LNPEP
LTC4S
MFSD5
MFSD6
MGAM
MS4A1
NDUFB11
NINJ2
NRM
NSG1
PAEP
PLP1
PLPP1
PMP22
PNLIPRP1
RPRM
RTP2
RUSF1
SCD
SERINC1
SERP2
SERTM1
SLC30A2
SLC30A3
SLC30A8
SLC35E4
SLC38A1
SLC38A7
SLC39A2
SLC41A1
SLC41A2
SMCO4
SMIM3
STATH
STRIT1
STX8
SYNDIG1
SYNGR1
TEX264
TF
TM4SF4
TMBIM6
TMEM140
TMEM147
TMEM182
TMEM19
TMEM237
TMEM239
TMEM242
TMEM262
TMEM30B
TMEM60
TMEM65
TRARG1
TREX1
TSPO2
YIF1A
YIPF1
YIPF2
YIPF4
YIPF6
ZFPL1
Entrez ID
3684
2866
HPRD ID
00411
16033
Ensembl ID
ENSG00000169896
ENSG00000126251
Uniprot IDs
P11215
A0A0K0PUY3
O15529
PDB IDs
1A8X
1BHO
1BHQ
1IDN
1IDO
1JLM
1M1U
1MF7
1N9Z
1NA5
2LKE
2LKJ
3Q3G
3QA3
4M76
4XW2
6RHW
Enriched GO Terms of Interacting Partners
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