ITGAM and CD209

Data Source:
HPRD (in vivo)

		ITGAM	CD209
Description		integrin subunit alpha M	CD209 molecule
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Host Cell
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding	Virus Receptor Activity Protein Binding Mannose Binding Carbohydrate Binding Peptide Antigen Binding Virion Binding Metal Ion Binding
	Biological Process	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Forebrain Development Positive Regulation Of Superoxide Anion Generation Toll-like Receptor 4 Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Leukocyte Migration Positive Regulation Of Protein Targeting To Membrane Apoptotic Signaling Pathway Amyloid-beta Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Hippocampal Neuron Apoptotic Process Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Prostaglandin-E Synthase Activity	Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Endocytosis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-cell Recognition Modulation By Virus Of Host Process Virion Attachment To Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of T Cell Proliferation Innate Immune Response Viral Entry Into Host Cell Peptide Antigen Transport Intracellular Transport Of Virus B Cell Adhesion Positive Regulation Of Viral Life Cycle
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	CD209 (DC-SIGN) signaling Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26502338 18204098 21408207 19165918 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Blood protein levels ( 30072576 29875488)
Interacting Genes		55 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35C2 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2	9 interacting genes: CEACAM1 CLEC4M CLU ICAM2 ICAM3 IFT20 ITGAM TCEAL8 VAC14
Entrez ID		3684	30835
HPRD ID		00411	05241
Ensembl ID		ENSG00000169896	ENSG00000090659
Uniprot IDs		P11215	B2R907 B4E2A8 M0R0P0 Q9NNX6 X6RB12
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW	1K9I 1SL4 1SL5 2B6B 2IT5 2IT6 2XR5 2XR6 6GHV
Enriched GO Terms of Interacting Partners?
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