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ITGAM and DKK4
Data Source:
BioGRID
(two hybrid)
ITGAM
DKK4
Description
integrin subunit alpha M
dickkopf WNT signaling pathway inhibitor 4
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Integrin AlphaM-beta2 Complex
Specific Granule Membrane
Plasma Membrane Raft
Extracellular Exosome
Tertiary Granule Membrane
Cellular_component
Extracellular Space
Molecular Function
Amyloid-beta Binding
Complement Component C3b Binding
Integrin Binding
Protein Binding
Heat Shock Protein Binding
Cargo Receptor Activity
Metal Ion Binding
Molecular_function
Protein Binding
Co-receptor Binding
Receptor Antagonist Activity
Biological Process
Microglial Cell Activation
Receptor-mediated Endocytosis
Phagocytosis, Engulfment
Cell Adhesion
Integrin-mediated Signaling Pathway
Ectodermal Cell Differentiation
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Forebrain Development
Positive Regulation Of Superoxide Anion Generation
Toll-like Receptor 4 Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of Neutrophil Degranulation
Innate Immune Response
Negative Regulation Of Dopamine Metabolic Process
Leukocyte Migration
Positive Regulation Of Protein Targeting To Membrane
Apoptotic Signaling Pathway
Amyloid-beta Clearance
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Hippocampal Neuron Apoptotic Process
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Positive Regulation Of Neuron Death
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Positive Regulation Of Prostaglandin-E Synthase Activity
Multicellular Organism Development
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Hair Follicle Placode Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signaling Receptor Activity
Pathways
Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signaling by LRP5 mutants
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) (
22922229
)
Graves' disease (
22922229
)
IgA nephropathy (
25305756
)
Serum metabolite levels (CMS) (
31636271
)
Systemic lupus erythematosus (
27399966
18204446
24871463
26606652
23273568
26502338
18204098
21408207
19165918
28714469
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Interacting Genes
55 interacting genes:
ABHD16A
AQP6
ARL13B
AUP1
C3
CD209
CD79A
CERS4
CFH
CLEC4M
CLRN1
CREB3L1
DKK4
ELANE
ELOVL4
ERGIC3
FGG
GJA8
GJB1
GORAB
GP1BA
GPR42
HP
HSD17B13
ICAM1
ICAM2
ICAM4
IRAK1
ITGB2
JAM3
KASH5
KCNJ6
KIR2DL3
LMNA
MGST3
MMGT1
MRM1
MUC1
PGRMC2
PIGP
PLAUR
REEP2
REEP4
RUSF1
SCN3B
SHARPIN
SLC10A6
SLC35C2
SYT2
THY1
TMEM14B
TMEM229B
TMEM31
TMEM52B
TMX2
3 interacting genes:
GIMAP5
ITGAM
TSPO2
Entrez ID
3684
27121
HPRD ID
00411
05660
Ensembl ID
ENSG00000169896
ENSG00000104371
Uniprot IDs
P11215
Q9UBT3
PDB IDs
1A8X
1BHO
1BHQ
1IDN
1IDO
1JLM
1M1U
1MF7
1N9Z
1NA5
2LKE
2LKJ
3Q3G
3QA3
4M76
4XW2
6RHW
5O57
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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