AQP7 and COMT

Data Source:
BioGRID (two hybrid)

		AQP7	COMT
Description		aquaporin 7	catechol-O-methyltransferase
Image
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Cortex Cytoplasmic Vesicle Membrane	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity
	Biological Process	Water Transport Glycerol Transport Urea Transmembrane Transport	Methylation Developmental Process Neurotransmitter Catabolic Process Dopamine Metabolic Process Catecholamine Catabolic Process
Pathways		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins	Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS
Drugs			Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Urinary albumin excretion ( 30220432)	Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		4 interacting genes: ABHD16A CLCN7 COMT MFSD6	68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2
Entrez ID		364	1312
HPRD ID		04277	00284
Ensembl ID		ENSG00000165269	ENSG00000093010
Uniprot IDs		B7Z4U2 O14520 Q5T5M0 Q5T5M1 Q6P5T0	A0A140VJG8 P21964
PDB IDs		6KXW 6N1G 6QZI 6QZJ	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?
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