Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CXCL8 and BAG6
Data Source:
BioGRID
(two hybrid)
CXCL8
BAG6
Description
C-X-C motif chemokine ligand 8
BAG cochaperone 6
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Extracellular Exosome
BAT3 Complex
Molecular Function
Interleukin-8 Receptor Binding
Protein Binding
Chemokine Activity
CXCR Chemokine Receptor Binding
Signaling Receptor Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Misfolded Protein Binding
Proteasome Binding
Ubiquitin-specific Protease Binding
Biological Process
Angiogenesis
Response To Molecule Of Bacterial Origin
Chemotaxis
Inflammatory Response
Cell Cycle Arrest
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Calcium-mediated Signaling
Regulation Of Cell Adhesion
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Receptor Internalization
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
PERK-mediated Unfolded Protein Response
Neutrophil Activation
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiogenesis
Embryonic Digestive Tract Development
Induction Of Positive Chemotaxis
Negative Regulation Of Cell Adhesion Molecule Production
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Entry Of Bacterium Into Host Cell
Kidney Development
Immune Response-activating Cell Surface Receptor Signaling Pathway
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Synaptonemal Complex Assembly
Spermatogenesis
Brain Development
Proteasomal Protein Catabolic Process
Internal Peptidyl-lysine Acetylation
Natural Killer Cell Activation
Cell Differentiation
Lung Development
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Proteolysis
Regulation Of Embryonic Development
Protein Stabilization
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
ER-associated Misfolded Protein Catabolic Process
Tail-anchored Membrane Protein Insertion Into ER Membrane
Positive Regulation Of ERAD Pathway
Maintenance Of Unfolded Protein Involved In ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways
Senescence-Associated Secretory Phenotype (SASP)
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
ATF4 activates genes in response to endoplasmic reticulum stress
G alpha (i) signalling events
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
ABT-510
MDX-018
Rivanicline
Tapinarof
Diseases
GWAS
Chronic kidney disease (
30226566
)
Coronary artery disease (
30402224
)
Hypertension (
30226566
)
Ischemic stroke (
29930801
)
Myocardial infarction (
30226566
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Height (
28552196
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Schizophrenia (
23894747
)
Small cell lung carcinoma (
28604730
)
Smoking status (ever vs never smokers) (
30643258
)
Ulcerative colitis (
28067908
)
Interacting Genes
20 interacting genes:
ACKR1
ARFGAP3
BAG6
CCL2
CCL4
CCL5
CCL8
CTSL
CXCR1
CXCR2
EP300
ERBB2
GNAI2
IL12A
MMP9
PF4
POMGNT1
SDC1
SGTA
WASF1
118 interacting genes:
ACVR1B
AMFR
AMTN
ANTKMT
ANXA7
APBB1IP
ARPC3
ATN1
ATXN2
B2M
C1QA
CD93
CDK16
CDK4
CDK5
CDKN1A
CDSN
CHN2
CILK1
CLU
CSNK2B
CSTF2
CTAG1A
CTAG1B
CTCFL
CTSB
CTSE
CTSL
CXCL8
CYSRT1
DMKN
DNAJB11
DPT
EDN1
EFEMP1
EFEMP2
ELP1
EP300
FAM9B
FAS
FKBP2
FZD4
GADD45A
GET4
GLRA2
GOLGA6L9
GSK3B
HSPA13
HSPA8
IGF2
IGFBP5
IMMT
IQCG
KLHL12
KPNA2
LBP
MAPK6
MEST
MTNR1A
MYDGF
NBL1
NCR3
NDUFA6
NDUFB11
NOMO1
NPY
NR1H2
PELP1
PIN1
PLA2G2A
PLK1
PLPP2
PLPPR3
POLR2J
PRKAR1B
PRMT2
PRNP
PRPF40A
PTH
PTN
PTPN12
RAB8A
RAC1
RCC1
RCN2
REG1B
RNF126
S100A4
SDC2
SEC61A1
SEC61B
SERPING1
SERPINH1
SERPINI2
SETDB1
SGTA
SMN1
SPP1
SRGN
STX5
TAC1
TDGF1
TENT5A
TFCP2
TK1
TOMM20
TP53
TP63
TTR
UBL4B
UBL7
UBQLN1
UBQLN2
UBQLN4
USP13
VAMP2
XRN1
ZFYVE9
Entrez ID
3576
7917
HPRD ID
00909
00808
Ensembl ID
ENSG00000169429
ENSG00000204463
Uniprot IDs
A0A024RDA5
P10145
A0A1U9X7A6
P46379
PDB IDs
1ICW
1IKL
1IKM
1IL8
1ILP
1ILQ
1QE6
1ROD
2IL8
3IL8
4XDX
5D14
5WDZ
6LFM
6LFO
6N2U
1WX9
2N9P
4DWF
4EEW
4WWR
4X86
6AU8
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?