CXCL8 and ARFGAP3

Data Source:
BioGRID (two hybrid)

		CXCL8	ARFGAP3
Description		C-X-C motif chemokine ligand 8	ADP ribosylation factor GTPase activating protein 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Cell Cycle Arrest Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Positive Regulation Of Cellular Biosynthetic Process Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Secretion Vesicle-mediated Transport Positive Regulation Of GTPase Activity COPI Coating Of Golgi Vesicle
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		ABT-510 MDX-018 Rivanicline Tapinarof
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)	Resting metabolic rate ( 28476931)
Interacting Genes		20 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1	8 interacting genes: APP CD14 CXCL8 LIME1 RTN4IP1 SMAD2 SYPL1 ZDHHC17
Entrez ID		3576	26286
HPRD ID		00909	06444
Ensembl ID		ENSG00000169429	ENSG00000242247
Uniprot IDs		A0A024RDA5 P10145	A0A024R4U0 Q9NP61
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U	2CRW
Enriched GO Terms of Interacting Partners?
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