EIF2AK2 and MIR140

Data Source:
BioGRID (unspecified method)

		EIF2AK2	MIR140
Description		eukaryotic translation initiation factor 2 alpha kinase 2	microRNA 140
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Extracellular Space
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Mitigation Of Host Immune Response By Virus Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Gene Silencing By MiRNA Defense Response To Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		ISG15 antiviral mechanism Inhibition of PKR
Drugs		Fostamatinib
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)	Body mass index ( 26426971)
Interacting Genes		124 interacting genes: ADARB1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 UBE2I ZNF346	68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3
Entrez ID		5610	406932
HPRD ID		01468
Ensembl ID		ENSG00000055332	ENSG00000208017
Uniprot IDs		P19525 Q8IW76
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L
Enriched GO Terms of Interacting Partners?
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