RSPO4 and USP20

Data Source:
BioGRID (two hybrid)

		RSPO4	USP20
Description		R-spondin 4	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Heparin Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Nail Development	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein Phosphopantetheinylation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Regulation of FZD by ubiquitination	Ub-specific processing proteases
Drugs
Diseases		Anonychia congenita
GWAS		Blood protein levels ( 30072576) Lean body mass ( 28552196) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321)	Metabolite levels ( 23823483)
Interacting Genes		15 interacting genes: ANKRD11 DHX57 GNG13 GPSM3 GUCD1 HGS KLHL38 LGR4 MAPK9 MKRN3 PIH1D2 STK16 USP20 ZNF330 ZNF77	69 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BHLHB9 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB
Entrez ID		343637	10868
HPRD ID		18788	07505
Ensembl ID		ENSG00000101282	ENSG00000136878
Uniprot IDs		Q2I0M5	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?
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