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USP20 and HAND2
Data Source:
BioGRID
(two hybrid)
USP20
HAND2
Description
ubiquitin specific peptidase 20
heart and neural crest derivatives expressed 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Transcription Regulator Complex
Protein-containing Complex
Molecular Function
G Protein-coupled Receptor Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Zinc Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Transcription Factor Binding
Activating Transcription Factor Binding
Protein Homodimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Regulation Of G Protein-coupled Receptor Signaling Pathway
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Angiogenesis
In Utero Embryonic Development
Heart Looping
Suckling Behavior
Cardiac Right Ventricle Formation
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Apoptotic Process Involved In Heart Morphogenesis
Noradrenergic Neuron Differentiation
Regulation Of Transcription By RNA Polymerase II
Heart Development
Adult Heart Development
Mesenchymal Cell Proliferation
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Developmental Process
Regulation Of Tissue Remodeling
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Tongue Development
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Thymus Development
Peripheral Nervous System Neuron Development
Cartilage Morphogenesis
Coronary Artery Morphogenesis
Visceral Serous Pericardium Development
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Cell Proliferation Involved In Outflow Tract Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of P38MAPK Cascade
Primary Palate Development
Positive Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process
Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis
Pathways
Ub-specific processing proteases
Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Atrial fibrillation (
28416822
30061737
29892015
)
Chin dimples (
27182965
)
Early onset atrial fibrillation (
28460022
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Epstein-Barr virus copy number in lymphoblastoid cell lines (
28654678
)
PR interval (
32439900
)
Interacting Genes
69 interacting genes:
AGR2
ALAS1
APBA2
ARID5A
ASCL1
ATP6V1G2
BEND5
BEND7
BHLHB9
BRPF1
C1QTNF2
CCNL2
CDK2AP1
CLSPN
CTAG1A
CTAG1B
DIO2
ENKD1
EPAS1
FATE1
FTO
GPRASP2
GTF2IRD1
HAND2
HIF1A
HSF2BP
IHO1
IRAK1BP1
ITGB3BP
KLHL20
LMNA
MAGEA11
MAPK6
MBD3L1
MCCD1
MDFI
MEOX2
MRPL28
PBX4
PJA1
PLA2G2A
PRKACA
PRKCI
RAD17
RSPO4
SAMD12
SPRY2
SRGAP2B
STING1
TNNI1
TRIB3
TRIM23
TTC19
TTC23L
ULK1
USP15
USP21
USP28
VAPA
VAPB
VAX1
VHL
WASHC1
ZBTB10
ZFYVE26
ZNF343
ZNF408
ZNF620
ZXDB
21 interacting genes:
CENPB
COPS5
DNMT3L
EP300
FAM90A1
GATA4
HAND1
HEY2
HEYL
KANK2
NPM1
PHOX2A
PPP2R5D
PRKACA
PRKCA
RIPPLY1
SPANXN3
TCF12
TCF3
TCF4
USP20
Entrez ID
10868
9464
HPRD ID
07505
03872
Ensembl ID
ENSG00000136878
ENSG00000164107
Uniprot IDs
Q9Y2K6
P61296
PDB IDs
6KCZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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