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USP20 and STING1
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study, affinity chromatography technology)
USP20
STING1
Description
ubiquitin specific peptidase 20
stimulator of interferon response cGAMP interactor 1
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Perinuclear Region Of Cytoplasm
Autophagosome Membrane
Nucleoplasm
Mitochondrial Outer Membrane
Endosome
Autophagosome
Peroxisome
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Cytoplasmic Vesicle Membrane
Secretory Granule Membrane
Perinuclear Region Of Cytoplasm
Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Molecular Function
G Protein-coupled Receptor Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Zinc Ion Binding
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Cyclic-di-GMP Binding
Identical Protein Binding
Protein Homodimerization Activity
Cyclic-GMP-AMP Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Regulation Of G Protein-coupled Receptor Signaling Pathway
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Autophagosome Assembly
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Viral Process
Positive Regulation Of Macroautophagy
Positive Regulation Of Protein Binding
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Interferon-beta Production
Cellular Response To Interferon-beta
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Positive Regulation Of DNA-binding Transcription Factor Activity
Protein Complex Oligomerization
Defense Response To Virus
Reticulophagy
Cellular Response To Exogenous DsRNA
Cellular Response To Organic Cyclic Compound
Pathways
Ub-specific processing proteases
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Neutrophil degranulation
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Interacting Genes
69 interacting genes:
AGR2
ALAS1
APBA2
ARID5A
ASCL1
ATP6V1G2
BEND5
BEND7
BHLHB9
BRPF1
C1QTNF2
CCNL2
CDK2AP1
CLSPN
CTAG1A
CTAG1B
DIO2
ENKD1
EPAS1
FATE1
FTO
GPRASP2
GTF2IRD1
HAND2
HIF1A
HSF2BP
IHO1
IRAK1BP1
ITGB3BP
KLHL20
LMNA
MAGEA11
MAPK6
MBD3L1
MCCD1
MDFI
MEOX2
MRPL28
PBX4
PJA1
PLA2G2A
PRKACA
PRKCI
RAD17
RSPO4
SAMD12
SPRY2
SRGAP2B
STING1
TNNI1
TRIB3
TRIM23
TTC19
TTC23L
ULK1
USP15
USP21
USP28
VAPA
VAPB
VAX1
VHL
WASHC1
ZBTB10
ZFYVE26
ZNF343
ZNF408
ZNF620
ZXDB
22 interacting genes:
CCDC47
CMTM5
DDOST
IRAK1
LEPROTL1
LTN1
MBOAT7
MUL1
PLLP
REEP6
RNF26
SGPL1
SMIM1
STT3A
STX5
SURF4
TECR
TMEM100
TRIM32
USP20
USP49
YIPF2
Entrez ID
10868
340061
HPRD ID
07505
14173
Ensembl ID
ENSG00000136878
ENSG00000184584
Uniprot IDs
Q9Y2K6
J3QTB1
Q86WV6
V5V0K2
PDB IDs
6KCZ
4EF4
4EF5
4EMT
4EMU
4F5D
4F5E
4F5W
4F5Y
4F9E
4F9G
4KSY
4LOH
4LOI
4QXO
4QXP
4QXQ
4QXR
5BQX
5JEJ
6CFF
6CY7
6DNK
6DXG
6DXL
6MX0
6MX3
6MXE
6NT5
6O8B
6O8C
6RM0
6S26
6S27
6S86
6UKM
6UKU
6UKV
6UKW
6UKX
6UKY
6UKZ
6UL0
6XNP
Enriched GO Terms of Interacting Partners
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