RSPO4 and ANKRD11

Data Source:
BioGRID (two hybrid)

		RSPO4	ANKRD11
Description		R-spondin 4	ankyrin repeat domain 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Heparin Binding
	Biological Process	Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Nail Development	Anatomical Structure Morphogenesis Odontogenesis Of Dentin-containing Tooth Skeletal System Morphogenesis Face Morphogenesis
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases		Anonychia congenita
GWAS		Blood protein levels ( 30072576) Lean body mass ( 28552196) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321)	Eosinophil counts ( 32888494) Hemoglobin levels ( 32327693) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494)
Interacting Genes		15 interacting genes: ANKRD11 DHX57 GNG13 GPSM3 GUCD1 HGS KLHL38 LGR4 MAPK9 MKRN3 PIH1D2 STK16 USP20 ZNF330 ZNF77	93 interacting genes: ABHD11 AGR2 ANKRD33 ARID3A ARID5A BHLHB9 BRCC3 C10orf82 C11orf1 C18orf54 C1QTNF2 CALCA CCDC196 CCHCR1 CCN3 CDC23 CDCA7L CDR2L CEP44 COG4 DEPTOR FAM136A FAM221B FOLR3 FTO GOLGA2 GOLGA6L9 GRIPAP1 HAUS3 HDAC3 HDAC4 HDAC5 HOMEZ HOOK2 HRAS IGFBP6 IKZF1 ITGB3BP KANK2 KPNA3 KPNA6 KRT34 LZTS2 MKRN3 MTFR1L MTUS2 MXRA8 MYF5 NAB2 NCOA1 NCOA2 NCOA3 NOTO NTAQ1 PDE4DIP PIH1D2 PLAGL2 PPARA RAC3 RCOR3 RINT1 RPH3AL RSPO4 RUBCN SERTAD3 SNRNP35 SPANXN2 SPATA2 SPRY1 SRC STMN3 STRA8 SYTL3 TADA2B TFIP11 TLE5 TNNI1 TRAF2 TRIM37 TRIM54 TSPOAP1 TTC23L TXN UFC1 USH1G USP54 USP6 VDR ZNF426 ZNF552 ZNF655 ZNF688 ZRANB1
Entrez ID		343637	29123
HPRD ID		18788	12456
Ensembl ID		ENSG00000101282	ENSG00000167522
Uniprot IDs		Q2I0M5	Q6UB99
PDB IDs
Enriched GO Terms of Interacting Partners?
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