LEUTX and AQP2

Data Source:
BioGRID (two hybrid)

		LEUTX	AQP2
Description		leucine twenty homeobox	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Macular thickness ( 30535121)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		46 interacting genes: AGPAT4 AIG1 AQP2 AQP3 ASGR1 C1GALT1 C1QL4 C3orf52 CDS2 CMTM3 CMTM5 CNIH1 CNIH3 CXCL9 EMP3 ENTPD3 FAM24B FZD7 GOSR2 KIR2DL3 LAT MRPL57 MS4A1 NAPB NDRG4 OLFM4 PLP1 PNLIPRP1 PRB1 SLC13A3 SLC30A8 SLC41A2 STATH TF TMEM128 TMEM147 TMEM187 TMEM254 TMEM60 TMEM97 TSPO TTPA UNC93B1 VAMP4 ZFPL1 ZNF646	60 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		342900	359
HPRD ID			00141
Ensembl ID		ENSG00000213921	ENSG00000167580
Uniprot IDs		A8MZ59	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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