IDE and INS

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		IDE	INS
Description		insulin degrading enzyme	insulin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Transport Vesicle Endosome Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Secretory Granule Lumen
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Ubiquitin-dependent Protein Binding	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Protein Targeting To Peroxisome Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Viral Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration	Positive Regulation Of Cytokine Production Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Transmembrane Transporter Activity Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Negative Regulation Of Protein Catabolic Process Glucose Homeostasis Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Synaptic Plasticity Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Cognition Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dendritic Spine Maintenance Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Negative Regulation Of Feeding Behavior
Pathways		Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import	Regulation of gene expression in beta cells Insulin processing Insulin processing Synthesis, secretion, and deacylation of Ghrelin Regulation of insulin secretion COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation
Drugs		Insulin pork Bacitracin	Zinc M-Cresol Myristic acid Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Maturity onset diabetes of the young (MODY) Type I diabetes mellitus Permanent neonatal diabetes mellitus (PNDM)
GWAS		Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 31043758 27680694) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 29358691 30297969 26818947 32499647 20581827 30718926) Waist-to-hip ratio adjusted for BMI ( 28552196)	Birth weight ( 27680694) Celiac disease ( 23936387) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 19767753) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes ( 30659077 21829393 17632545 25751624 32005708 19430480 17554260 31152121) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 30297969 31049640 32499647 30718926)
Interacting Genes		9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5	31 interacting genes: ADAMTSL4 APP CCN3 CPE CRYAB CTSB CTSD CTSE CYSRT1 GCK HLA-DQA2 HLA-DQB1 HSPA1A HSPB1 IDE IGF1R IGFBP7 INSR KMT2A KRTAP1-1 KRTAP1-3 LRP2 MAPK6 NBPF19 NOTCH2NLA PTEN RB1 RGS20 SYTL4 TCF4 TXNDC17
Entrez ID		3416	3630
HPRD ID		00894	01455
Ensembl ID		ENSG00000119912	ENSG00000254647
Uniprot IDs		A0A3B3ISG5 B3KSB8 P14735	I3WAC9 P01308
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2MLI 2MPG 2MPI 2MVC 2MVD 2N2V 2N2W 2N2X 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2OMQ 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4CXL 4CXN 4CY7 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 4IYD 4IYF 4NIB 4OGA 4P65 4RXW 4UNE 4UNG 4UNH 4WDI 4XC4 4Y19 4Y1A 4Z76 4Z77 4Z78 5AIY 5BOQ 5BPO 5BQQ 5BTS 5C0D 5CJO 5CNY 5CO2 5CO6 5CO9 5E7W 5EMS 5EN9 5ENA 5HPR 5HPU 5HQI 5HRQ 5HYJ 5MAM 5MHD 5MT3 5MT9 5MWQ 5T7R 5UDP 5UOZ 5UQA 5URT 5URU 5USP 5USS 5USV 5UU2 5UU3 5UU4 5VIZ 5WBT 5WDM 5WOB 6B3Q 6B70 6BFC 6CE7 6CE9 6CEB 6CK2 6GNQ 6GV0 6H3M 6HN5 6JK8 6JR3 6K59 6NWV 6O17 6P4Z 6S34 6S4I 6S4J 6SOF 6TYH 6U46 6VEP 6VET 6X4X
Enriched GO Terms of Interacting Partners?
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