IDE and IGF2

Data Source:
HPRD (in vitro)

		IDE	IGF2
Description		insulin degrading enzyme	insulin like growth factor 2
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Ubiquitin-dependent Protein Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Proteolysis Protein Targeting To Peroxisome Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Viral Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Regulation Of Histone Modification Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Embryonic Placenta Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Insulin pork Bacitracin
Diseases			Beckwith-Wiedemann syndrome Russell-Silver syndrome; Silver-Russell syndrome Adrenal carcinoma
GWAS		Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 31043758 27680694) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 29358691 30297969 26818947 32499647 20581827 30718926) Waist-to-hip ratio adjusted for BMI ( 28552196)	Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 32499647 30718926) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5	26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN
Entrez ID		3416	3481
HPRD ID		00894	00939
Ensembl ID		ENSG00000119912	ENSG00000167244
Uniprot IDs		A0A3B3ISG5 B3KSB8 P14735	E3UN46 P01344
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3	1GF2 1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI
Enriched GO Terms of Interacting Partners?
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