IDE and PEX5

Data Source:
BioGRID (unspecified method)

		IDE	PEX5
Description		insulin degrading enzyme	peroxisomal biogenesis factor 5
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Ubiquitin-dependent Protein Binding	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding Protein Sequestering Activity
	Biological Process	Proteolysis Protein Targeting To Peroxisome Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Viral Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Protein Import Into Peroxisome Membrane
Pathways		Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import	Pexophagy
Drugs		Insulin pork Bacitracin
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 31043758 27680694) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 29358691 30297969 26818947 32499647 20581827 30718926) Waist-to-hip ratio adjusted for BMI ( 28552196)	IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5	76 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772
Entrez ID		3416	5830
HPRD ID		00894	02684
Ensembl ID		ENSG00000119912	ENSG00000139197
Uniprot IDs		A0A3B3ISG5 B3KSB8 P14735	A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?