KRTAP19-2 and HSD3B7

Data Source:
BioGRID (two hybrid)

		KRTAP19-2	HSD3B7
Description		keratin associated protein 19-2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	Protein Binding	3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Keratinization	Bile Acid Biosynthetic Process B Cell Chemotaxis
Pathways		Keratinization	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Interacting Genes		46 interacting genes: ADAMTSL4 ANAPC11 ATN1 C11orf16 CHRD COL8A1 CREB5 CYSRT1 EFEMP1 ETHE1 FBLN1 FOXD2 FOXH1 GNE HOXC8 HSD3B7 KPRP KRTAP12-2 KRTAP12-4 KRTAP3-3 KRTAP4-12 KRTAP6-3 KRTAP9-3 LCE2D MEIS2 MGAT5B MKRN3 NTAQ1 OLIG3 OTX1 PCSK5 PIGS POU4F2 RHBG SLC12A4 SLC15A3 SMARCC1 SNRPC SPAG8 TEKT4 TENT5D TFAP2D VENTX VGLL3 VWC2L ZIC1	58 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 RUSF1 SPRY2 SSC4D TMEM31 TMX2 TRIM42 YPEL3 ZBTB42 ZNF655
Entrez ID		337969	80270
HPRD ID		11206	09680
Ensembl ID		ENSG00000186965	ENSG00000099377
Uniprot IDs		Q3LHN2	Q9H2F3
PDB IDs
Enriched GO Terms of Interacting Partners?
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