DNAJB1 and PLEKHO1

Data Source:
BioGRID (two hybrid)

		DNAJB1	PLEKHO1
Description		DnaJ heat shock protein family (Hsp40) member B1	pleckstrin homology domain containing O1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJA2 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TP53 TTLL12 ZFP36	32 interacting genes: ADAM33 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C4orf3 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1
Entrez ID		3337	51177
HPRD ID		05198	12217
Ensembl ID		ENSG00000132002	ENSG00000023902
Uniprot IDs		P25685 Q6FHS4	Q53GL0 Q5T4P9
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR	3AA1
Enriched GO Terms of Interacting Partners?
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