DDIT4 and HSPA4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DDIT4	HSPA4
Description		DNA damage inducible transcript 4	heat shock protein family A (Hsp70) member 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Protein Binding 14-3-3 Protein Binding	Protein Binding ATP Binding
	Biological Process	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction	Response To Unfolded Protein Protein Insertion Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways		TP53 Regulates Metabolic Genes	Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324) Refractive error ( 32231278)	Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels ( 32203549 31928498 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		7 interacting genes: GSK3B HSPA4 HSPB2 LRIF1 LRRK2 PDPK1 TXNIP	70 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A
Entrez ID		54541	3308
HPRD ID		09662	09025
Ensembl ID		ENSG00000168209	ENSG00000170606
Uniprot IDs		A0A024QZQ6 Q9NX09	P34932
PDB IDs		3LQ9
Enriched GO Terms of Interacting Partners?
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