HSPA2 and EWSR1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPA2	EWSR1
Description		heat shock protein family A (Hsp70) member 2	EWS RNA binding protein 1
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GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Glycolipid Binding Disordered Domain Specific Binding	Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Positive Regulation Of ATPase Activity Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Regulation Of Transcription, DNA-templated
Pathways		Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase
Drugs		Quercetin
Diseases			Ewing's sarcoma Myxoid liposarcoma Clear cell sarcoma of soft tissue Extraskeletal myxoid chondrosarcoma
GWAS			Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)
Interacting Genes		10 interacting genes: APP BAG4 CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38	162 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRMT8 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		3306	2130
HPRD ID		07174	00592
Ensembl ID		ENSG00000126803	ENSG00000182944
Uniprot IDs		A0A024R6B5 P54652	Q01844
PDB IDs		3I33 4FSV 5FPD 5FPE 5FPM 5FPN	2CPE
Enriched GO Terms of Interacting Partners?
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