HPN and SFTPC

Data Source:
BioGRID (two hybrid)

		HPN	SFTPC
Description		hepsin	surfactant protein C
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Serine-type Exopeptidase Activity	Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Respiratory Gaseous Exchange By Respiratory System Cellular Protein Metabolic Process
Pathways		MET Receptor Activation Signaling by MST1	Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Diseases			Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum albumin level ( 23022100) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2	36 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 PVR SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2
Entrez ID		3249	6440
HPRD ID		00801	01520
Ensembl ID		ENSG00000105707	ENSG00000168484
Uniprot IDs		A0A140VJK9 B7Z1L4 P05981	A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N 5CE1	2YAD
Enriched GO Terms of Interacting Partners?
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