HOXB1 and PKNOX2

Data Source:
HPRD (in vitro)

		HOXB1	PKNOX2
Description		homeobox B1	PBX/knotted 1 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Domain Specific Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Actin Monomer Binding Protein Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Pattern Specification Process Anterior/posterior Pattern Specification Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis	Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Body mass index ( 26426971) Colorectal or endometrial cancer ( 26621817) Hemoglobin levels ( 32327693) Primary tooth development (number of teeth) ( 20195514) Waist circumference ( 28552196)	Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439 21703634) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)
Interacting Genes		10 interacting genes: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 RCHY1 SERPINA3 ZNF835	32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PBX4 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C
Entrez ID		3211	63876
HPRD ID		00855	17857
Ensembl ID		ENSG00000120094	ENSG00000165495
Uniprot IDs		P14653	Q96KN3
PDB IDs		1B72
Enriched GO Terms of Interacting Partners?
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