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HNRNPA2B1 and LIG4
Data Source:
BioGRID
(two hybrid)
HNRNPA2B1
LIG4
Description
heterogeneous nuclear ribonucleoprotein A2/B1
DNA ligase 4
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Cajal Body
Membrane
Nuclear Matrix
Extracellular Exosome
Catalytic Step 2 Spliceosome
Ribonucleoprotein Complex
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Cytoplasmic Ribonucleoprotein Granule
Nonhomologous End Joining Complex
Molecular Function
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
MiRNA Binding
Single-stranded Telomeric DNA Binding
Pre-mRNA Intronic Binding
G-rich Strand Telomeric DNA Binding
N6-methyladenosine-containing RNA Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Splicing, Via Spliceosome
MRNA Processing
MRNA Export From Nucleus
Viral Process
RNA Metabolic Process
Primary MiRNA Processing
Interleukin-12-mediated Signaling Pathway
G-quadruplex DNA Unwinding
Negative Regulation Of MRNA Splicing, Via Spliceosome
RNA Transport
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity
MiRNA Transport
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Gamma Radiation
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Chromosome Organization
Pathways
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Drugs
Copper
Artenimol
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Interacting Genes
97 interacting genes:
ARID4B
CDKN2A
CSNK2A1
CSNK2B
ENY2
ERG
ESR1
H3-4
HIPK3
HNRNPL
HSPB1
LIG4
MAP4K2
MCPH1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NR4A1
SNRNP70
SREK1
STAT5B
SUMO2
TRAPPC12
TRIM35
TTF2
VHL
YAE1
ZMYM2
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
Entrez ID
3181
3981
HPRD ID
02526
03500
Ensembl ID
ENSG00000122566
ENSG00000174405
Uniprot IDs
P22626
A0A024RE06
A0A0C4DGV9
A8K8Q4
P49917
PDB IDs
1X4B
5EN1
5HO4
5WWE
5WWF
5WWG
6WPQ
6WQK
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
Enriched GO Terms of Interacting Partners
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