HNRNPA2B1 and HIPK3

Data Source:
BioGRID (unspecified method)

		HNRNPA2B1	HIPK3
Description		heterogeneous nuclear ribonucleoprotein A2/B1	homeodomain interacting protein kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Single-stranded Telomeric DNA Binding Pre-mRNA Intronic Binding G-rich Strand Telomeric DNA Binding N6-methyladenosine-containing RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Viral Process RNA Metabolic Process Primary MiRNA Processing Interleukin-12-mediated Signaling Pathway G-quadruplex DNA Unwinding Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Transport Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity MiRNA Transport	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Copper Artenimol	Fostamatinib
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anger ( 24489884) Obese vs. thin ( 30677029) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		97 interacting genes: ARID4B CDKN2A CSNK2A1 CSNK2B ENY2 ERG ESR1 H3-4 HIPK3 HNRNPL HSPB1 LIG4 MAP4K2 MCPH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NR4A1 SNRNP70 SREK1 STAT5B SUMO2 TRAPPC12 TRIM35 TTF2 VHL YAE1 ZMYM2	37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX
Entrez ID		3181	10114
HPRD ID		02526	05111
Ensembl ID		ENSG00000122566	ENSG00000110422
Uniprot IDs		P22626	A8KAE4 Q9H422
PDB IDs		1X4B 5EN1 5HO4 5WWE 5WWF 5WWG 6WPQ 6WQK
Enriched GO Terms of Interacting Partners?
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