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HMOX1 and SEC11C
Data Source:
BioGRID
(two hybrid)
HMOX1
SEC11C
Description
heme oxygenase 1
SEC11 homolog C, signal peptidase complex subunit
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleolus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Caveola
Membrane
Perinuclear Region Of Cytoplasm
Signal Peptidase Complex
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Molecular Function
Heme Oxygenase (decyclizing) Activity
Phospholipase D Activity
Structural Molecule Activity
Protein Binding
Enzyme Binding
Heme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Biological Process
Angiogenesis
Endothelial Cell Proliferation
Wound Healing Involved In Inflammatory Response
Negative Regulation Of Leukocyte Migration
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Excretion
Regulation Of Blood Pressure
Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Muscle Cell Apoptotic Process
Smooth Muscle Hyperplasia
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
Cellular Response To Nutrient
Positive Regulation Of Chemokine Production
Negative Regulation Of Mast Cell Cytokine Production
Erythrocyte Homeostasis
Low-density Lipoprotein Particle Clearance
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron
Cellular Response To Heat
Response To Nicotine
Intracellular Signal Transduction
Heme Catabolic Process
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Response To Estrogen
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of DNA-binding Transcription Factor Activity
Iron Ion Homeostasis
Cellular Response To Arsenic-containing Substance
Cellular Response To Cadmium Ion
Cellular Response To Hypoxia
Cellular Response To Cisplatin
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Liver Regeneration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Signal Peptide Processing
Pathways
Heme degradation
Interleukin-4 and Interleukin-13 signaling
Iron uptake and transport
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
NADH
Formic acid
Biliverdine IX Alpha
12-Phenylheme
2-Phenylheme
Verdoheme
Stannsoporfin
1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS
Hippocampal volume in mild cognitive impairment (
29274321
)
Obesity-related traits (
23251661
)
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (
29748315
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Alzheimer's disease (age of onset) (
22005931
)
Chronotype (
30696823
)
Morning person (
30696823
)
Interacting Genes
40 interacting genes:
AKT1
AQP6
ARL13B
ASL
BLVRB
CD79A
COQ9
CPLX4
CPSF1
CRB3
CREB3
CYB561
CYBRD1
ELOVL4
ELOVL5
ELOVL6
ERGIC3
FAM174A
FAM209A
FAM210B
GPR152
JAGN1
KASH5
LMNA
MSMO1
NOS1
PDZK1IP1
POR
POT1
PTGER4
SEC11C
SLC16A7
SMO
STX1A
TERF1
TLCD4
TM4SF19
TMEM14B
TMIE
TUT1
23 interacting genes:
BTN2A2
C2
CADM3
GLP1R
HMOX1
MFF
PLPP6
PRSS23
RTP2
SCD
SELENOM
SERP1
STX12
TMEM128
TMEM243
TMEM254
TMEM42
TREX1
TSNARE1
UBE2J1
VAMP1
VAMP4
VAPA
Entrez ID
3162
90701
HPRD ID
00782
15310
Ensembl ID
ENSG00000100292
ENSG00000166562
Uniprot IDs
P09601
Q6FH11
K7EJQ7
Q9BY50
PDB IDs
1N3U
1N45
1NI6
1OYK
1OYL
1OZE
1OZL
1OZR
1OZW
1S13
1S8C
1T5P
1TWN
1TWR
1XJZ
1XK0
1XK1
1XK2
1XK3
3CZY
3HOK
3K4F
3TGM
4WD4
5BTQ
6EHA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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