HMOX1 and STX1A

Data Source:
BioGRID (two hybrid)

		HMOX1	STX1A
Description		heme oxygenase 1	syntaxin 1A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Postsynaptic Density Integral Component Of Membrane Secretory Granule Integral Component Of Synaptic Vesicle Membrane Axon SNARE Complex Nuclear Membrane Actomyosin Neuron Projection Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Structural Molecule Activity Protein Binding Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway Cellular Response To Nutrient Positive Regulation Of Chemokine Production Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Liver Regeneration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Exocytosis Vesicle Fusion Neurotransmitter Secretion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Protein Sumoylation Calcium-ion Regulated Exocytosis Cytokine-mediated Signaling Pathway Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Malaria ( 31844061) Triglyceride levels ( 32203549)
Interacting Genes		40 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDZK1IP1 POR POT1 PTGER4 SEC11C SLC16A7 SMO STX1A TERF1 TLCD4 TM4SF19 TMEM14B TMIE TUT1	167 interacting genes: AARD ABCC9 ABI3 AGTRAP AIG1 ANKRD46 AOC3 APBA1 APOL2 APOL3 AQP3 ARL13B ATP4B ATP6V1B1 BET1 BLOC1S6 BNIP1 BTN2A2 C1GALT1 C4orf3 CACNA1D CCSER2 CD81 CDC37 CDK5 CFTR CLEC1A CLN6 CMTM7 CPLX1 CSNK2A1 CSNK2A2 CXCL16 CYB5B DAPK1 DDX49 EBAG9 EMD ERG28 ETNK2 FAM3C GIMAP1 GIMAP5 GOLM2 GOSR2 GPM6B HMOX1 JAGN1 KCNB1 KIFC3 MAL MALL MIP MMGT1 NAPA NAPB NINJ2 NKG7 NRM NSF PGAP2 PLN PLP1 PLPP4 PLPP6 PNLIPRP1 PSMA3 RAB27A RAB3IL1 RIMS1 RMDN2 RNF4 RTP2 SCNN1A SCNN1B SCNN1G SDCBP SEC22A SEC22B SEPTIN2 SEPTIN5 SERP1 SERP2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SMIM1 SMIM3 SNAP23 SNAP25 SNAP29 SNAP47 SNORC SNPH STRIT1 STX10 STX11 STX12 STX16 STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TCEANC TMEM100 TMEM120A TMEM128 TMEM14C TMEM199 TMEM222 TMEM254 TMEM41A TMEM60 TNF TRAF3IP3 TRDMT1 TSGA10IP TSNARE1 TXLNA TXLNB UBE2I UBTFL1 UNC13B UPK1B USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS16 VPS18 VSTM4 VTI1B ZFPL1 ZNF12 ZNF136 ZNF250 ZNF440 ZNF441 ZNF479 ZNF490 ZNF557 ZNF696 ZNF707 ZNF785 ZNF835
Entrez ID		3162	6804
HPRD ID		00782	01721
Ensembl ID		ENSG00000100292	ENSG00000106089
Uniprot IDs		P09601 Q6FH11	Q16623 Q75ME0
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA
Enriched GO Terms of Interacting Partners?
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