HMOX1 and MSMO1

Data Source:
BioGRID (two hybrid)

		HMOX1	MSMO1
Description		heme oxygenase 1	methylsterol monooxygenase 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Structural Molecule Activity Protein Binding Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	C-4 Methylsterol Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway Cellular Response To Nutrient Positive Regulation Of Chemokine Production Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Liver Regeneration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Fatty Acid Metabolic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Sterol Biosynthetic Process
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Cholesterol biosynthesis
Drugs		NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone	NADH
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Heel bone mineral density ( 30598549) Neuroticism ( 27067015)
Interacting Genes		40 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDZK1IP1 POR POT1 PTGER4 SEC11C SLC16A7 SMO STX1A TERF1 TLCD4 TM4SF19 TMEM14B TMIE TUT1	18 interacting genes: ATXN1 CHRM5 CYP4F22 DNAJC30 ERG28 GOLT1A GPR35 HMOX1 MMP14 STRIT1 STX3 TMEM11 TMEM140 TMEM242 TMEM65 TMEM86B VKORC1 YIF1A
Entrez ID		3162	6307
HPRD ID		00782	07396
Ensembl ID		ENSG00000100292	ENSG00000052802
Uniprot IDs		P09601 Q6FH11	Q15800
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA
Enriched GO Terms of Interacting Partners?
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