MID2 and PRPF31

Data Source:
BioGRID (two hybrid, two hybrid)

		MID2	PRPF31
Description		midline 2	pre-mRNA processing factor 31
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GO Annotations	Cellular Component	Cytoplasm Microtubule Extracellular Exosome	Nucleus Nucleoplasm U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex
	Molecular Function	Transcription Coactivator Activity Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Homodimerization Activity Phosphoprotein Binding	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding SnRNP Binding
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Viral Transcription Protein Localization To Microtubule Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome SnoRNA Localization Ribonucleoprotein Complex Localization
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS			Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)
Interacting Genes		238 interacting genes: ADAMTSL4 AEN ALDH3B1 ANKS1A AP1M1 AQP1 ARHGEF5 ATRIP AXIN1 BAHD1 BCL6B BLK BLZF1 BRCA1 BRMS1L BYSL C1orf35 CALCOCO2 CARD9 CARHSP1 CBX8 CCDC120 CCDC185 CCDC187 CCDC33 CCDC42 CCHCR1 CDK18 CEP57L1 CFP CHD2 CNNM3 COX5B CPSF4 CRACR2A CREBRF CTSZ DCX DGCR6 DGCR6L DMRT3 DYDC1 EFHC2 EGFL7 EIF1AD ELOA ENKD1 EPN2 ETNK2 FAM107A FAM161A FAM161B FAM214A FAM214B FAM50B FAM90A1 FARS2 FASTKD5 FBF1 FBXL18 FBXW5 FOXD4L3 FRMD6 FSD2 GAS2L2 GAS8 GCC1 GEM GFI1B GMCL1 GOLGA2 GOLGA7 GORASP2 GPANK1 GPKOW GSC2 HAPLN2 HCK HDAC4 HDX HNRNPLL HOXB2 HOXB5 HOXB9 IGBP1 IGFN1 IHO1 IKZF3 IL16 INO80B IQCN ISCU ITGB4 JOSD1 KANK2 KIF1A KIF9 KIFC3 KRT27 KRT31 KRT40 KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS8 LMNB2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LRRC45 LZTS1 LZTS2 MAGEA6 MAGOHB MEOX1 MEOX2 METTL17 MFAP1 MID1 MID1IP1 MOS MVP NCOA4 NR1D2 NSMF NXF1 OTUB2 PICK1 PKN1 POLDIP3 PPP1R18 PRDM16 PRPF3 PRPF31 PSMA1 PTCD2 PTPDC1 QARS1 RABGEF1 RANBP3L RCOR3 REL RLN1 RNF6 RORB RPH3AL RPP25L RUNX1T1 RXRB SCNM1 SDCBP SEPTIN1 SHFL SLC25A48 SLC25A6 SNAI1 SNAP47 SPAG5 SPATA24 SPG21 SPRY2 STX11 SYNGAP1 SYT17 TASOR2 TBC1D22B TCAF1 TCEA2 TCEANC TEKT1 THAP7 TMEM14B TOP3B TRIM27 TRIM29 TRIM32 TRIM41 TRIM42 TRIM54 TRIM69 TRPV6 TSGA10 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K UBE2U UBTD1 UNC45A USP2 USP25 USP54 UTP23 UTP25 WT1-AS ZBTB16 ZBTB24 ZBTB42 ZC2HC1C ZFYVE21 ZGPAT ZIM2 ZNF124 ZNF165 ZNF177 ZNF24 ZNF250 ZNF266 ZNF408 ZNF410 ZNF417 ZNF438 ZNF440 ZNF451 ZNF497 ZNF552 ZNF559-ZNF177 ZNF564 ZNF587 ZNF648 ZNF669 ZNF688 ZNF696 ZNF764 ZNF774 ZNF784 ZNF785 ZNF792 ZRANB1 ZSCAN12	135 interacting genes: ASB15 BHLHB9 BICD2 C1QTNF1 CALCOCO2 CAPNS2 CARD14 CBY2 CCDC106 CCDC136 CCDC33 CCDC57 CCDC70 CCNDBP1 CDC23 CDCA7L CDR2L CEP70 CYSRT1 DVL2 DVL3 EFEMP2 EVI5 FANCA FANCC FASTK FLACC1 FSD2 FXR1 GOLGA2 GOLGA6L9 HAP1 HES7 HNRNPH2 HNRNPK HOOK2 HSF2BP JAKMIP2 KANK2 KCTD6 KHDRBS2 KHDRBS3 KIFC3 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP4-11 KRTAP6-3 LBX1 LDOC1 LHX8 LURAP1 LZTS2 MDFI MEIS3 MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NCKIPSD NOTCH2NLA PAK5 PDE4DIP PHC2 PHF5A PICK1 PLEKHG4 PNMA1 PNMA2 PNMA3 PPIH PPP1R16A PPP2R3C PRDM14 PRICKLE1 PRPF3 PSTPIP1 RACK1 RBAK RBM25 RBM4 RBMX RBMY1A1 RBMY1F RBMY1J REL RINT1 RUNDC3A SIAH1 SLAIN1 SNRNP200 SRSF3 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM14 TRIM23 TRIM27 TRIM41 TSGA10 UBXN11 USH1G USP15 VWC2 ZFP64 ZFP69B ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF48 ZNF587 ZNF668 ZNF71 ZNF774 ZNF792 ZNF837 ZRANB1 ZSCAN22
Entrez ID		11043	26121
HPRD ID		02191	05917
Ensembl ID		ENSG00000080561	ENSG00000105618
Uniprot IDs		Q6GX22 Q9UJV3	Q8WWY3
PDB IDs		2DJA 2DMK	2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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