Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
GZMB and CASP8
Data Source:
BioGRID
(enzymatic study)
GZMB
CASP8
Description
granzyme B
caspase 8
Image
GO Annotations
Cellular Component
Immunological Synapse
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Serine-type Peptidase Activity
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Apoptotic Process
Negative Regulation Of Translation
Cytolysis
Natural Killer Cell Mediated Cytotoxicity
Proteolysis Involved In Cellular Protein Catabolic Process
Pyroptosis
Granzyme-mediated Programmed Cell Death Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Angiogenesis
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Cold
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Natural Killer Cell Activation
Macrophage Differentiation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Toll-like Receptor 3 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Suppression By Virus Of Host Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
T Cell Activation
B Cell Activation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Response To Antibiotic
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptosis
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Cyclic Compound
Death-inducing Signaling Complex Assembly
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Activation Of Cysteine-type Endopeptidase Activity
Self Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
NOTCH2 intracellular domain regulates transcription
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Drugs
Bryostatin 1
Bardoxolone
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Blood protein levels (
30072576
29875488
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Vitiligo (
20410501
27723757
)
Basal cell carcinoma (
28177523
25855136
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
28165464
26956414
23770605
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte counts (
27863252
)
Melanoma (
21983787
28212542
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
White blood cell count (
32888494
)
Interacting Genes
26 interacting genes:
BID
CASP3
CASP7
CASP8
CASP9
CD2AP
CHRM3
DFFA
GRIA3
IGF2R
LMNA
LMNB1
PARP1
PRF1
PRKDC
PTGES3
PTK2
RAB27A
SERPINB9
SRGN
TUBA1A
UBE4A
UBE4B
XRCC4
XRCC5
XRCC6
132 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
TRAF6
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
Entrez ID
3002
841
HPRD ID
00476
03459
Ensembl ID
ENSG00000100453
ENSG00000064012
Uniprot IDs
J3KQ52
P10144
Q67BC3
Q6XGZ4
A0A024R3Z8
Q14790
PDB IDs
1FQ3
1IAU
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?