GZMB and DFFA

Data Source:
HPRD (in vitro, in vivo)

		GZMB	DFFA
Description		granzyme B	DNA fragmentation factor subunit alpha
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Protein Binding Protein Domain Specific Binding Protein Folding Chaperone Deoxyribonuclease Inhibitor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Apoptotic DNA Fragmentation Negative Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Chaperone-mediated Protein Folding Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation
Pathways		NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)	Depression in smokers ( 30219690) Male-pattern baldness ( 29146897 28196072)
Interacting Genes		26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	11 interacting genes: CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ
Entrez ID		3002	1676
HPRD ID		00476	03531
Ensembl ID		ENSG00000100453	ENSG00000160049
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	A0A024R4H5 O00273
PDB IDs		1FQ3 1IAU	1IBX 1IYR 1KOY
Enriched GO Terms of Interacting Partners?
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