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GZMB and PTK2
Data Source:
HPRD
(in vitro)
GZMB
PTK2
Description
granzyme B
protein tyrosine kinase 2
Image
GO Annotations
Cellular Component
Immunological Synapse
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Stress Fiber
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cell Cortex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ciliary Basal Body
Dendritic Spine
Intracellular Membrane-bounded Organelle
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Serine-type Peptidase Activity
Actin Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
JUN Kinase Binding
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
Biological Process
Apoptotic Process
Negative Regulation Of Translation
Cytolysis
Natural Killer Cell Mediated Cytotoxicity
Proteolysis Involved In Cellular Protein Catabolic Process
Pyroptosis
Granzyme-mediated Programmed Cell Death Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
MAPK Cascade
Angiogenesis
Placenta Development
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Heart Morphogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Endothelial Cell Migration
Regulation Of Epithelial Cell Migration
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Cell-cell Adhesion
Establishment Of Cell Polarity
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Detection Of Muscle Stretch
Netrin-activated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Cell Motility
Regulation Of Cytoskeleton Organization
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Wound Healing
Positive Regulation Of Macrophage Proliferation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Anoikis
Pathways
NOTCH2 intracellular domain regulates transcription
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Signal regulatory protein family interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
FCGR3A-mediated phagocytosis
Drugs
Endostatin
7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
Fostamatinib
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Vitiligo (
20410501
27723757
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
Apolipoprotein B levels (
32203549
)
Atrial fibrillation (
30061737
29892015
)
Deep white matter hyperintensities (
32517579
)
Diastolic blood pressure (
30224653
)
LDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin (
27863252
)
Mood instability (
31168069
)
Nickel levels (
26025379
)
PR interval (
32439900
)
Red cell distribution width (
32888494
)
Response to interferon beta therapy (
21502966
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
26 interacting genes:
BID
CASP3
CASP7
CASP8
CASP9
CD2AP
CHRM3
DFFA
GRIA3
IGF2R
LMNA
LMNB1
PARP1
PRF1
PRKDC
PTGES3
PTK2
RAB27A
SERPINB9
SRGN
TUBA1A
UBE4A
UBE4B
XRCC4
XRCC5
XRCC6
113 interacting genes:
ACTN1
APP
ARHGAP26
ASAP1
ATG12
BBS10
BCAR1
BIN1
BMX
CCR5
CD47
CD79B
CIB1
CRK
CSK
CSPG4
CXCR4
DCC
DDX39A
DEF6
DLGAP3
DNM2
DOK4
EEF1G
EFS
EGFR
EPHA2
EPHB2
EPS8L2
ERBB2
ERBB3
EZR
F13A1
FBP1
FGR
FLT1
FLT4
FYN
GIT1
GRB2
GRB7
GSK3B
GZMB
HES1
IGHM
INSR
IRS1
ITGAV
ITGB1
ITGB2
ITGB3
ITGB4
ITGB5
JAK2
KCNMA1
LCK
LPXN
LYN
MAPK8IP3
MDM2
MICAL1
NACAD
NASP
NCK1
NCK2
NEDD8
NEDD9
NEO1
PDGFRB
PIAS1
PIK3R1
PIK3R3
PKD1
PLCG1
PPP1CB
PTEN
PTK2B
PTPN11
PTPN12
PTPRH
PXN
RAC1
RB1CC1
RET
RIPK1
ROCK1
SAE1
SELE
SH2D1A
SH2D1B
SHC1
SOCS1
SOCS2
SOCS3
SORBS1
SRC
SRPK1
STAT1
SYK
TGFB1I1
TLN1
TNFRSF1A
TNS1
TNS3
TP53
TRIM15
TRIO
TRIP6
TSC2
VCL
YES1
ZFYVE21
ZNF331
Entrez ID
3002
5747
HPRD ID
00476
02859
Ensembl ID
ENSG00000100453
ENSG00000169398
Uniprot IDs
J3KQ52
P10144
Q67BC3
Q6XGZ4
Q05397
Q59GM6
Q59GN8
Q658W2
PDB IDs
1FQ3
1IAU
1K04
1K05
1MP8
1OW6
1OW7
1OW8
2ETM
2IJM
3B71
3BZ3
3PXK
3S9O
4EBV
4EBW
4GU6
4GU9
4I4E
4I4F
4K8A
4K9Y
4KAB
4KAO
4NY0
4Q9S
6I8Z
6LES
6PW8
Enriched GO Terms of Interacting Partners
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