PACSIN1 and PACSIN2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		PACSIN1	PACSIN2
Description		protein kinase C and casein kinase substrate in neurons 1	protein kinase C and casein kinase substrate in neurons 2
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Nuclear Speck Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding Identical Protein Binding	Transporter Activity Protein Binding Phospholipid Binding Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding
	Biological Process	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Membrane Organization Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation
Pathways		Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 28552196)	Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Prostate cancer (SNP x SNP interaction) ( 22219177)
Interacting Genes		25 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	16 interacting genes: COBL DNM1 FASLG GSC2 MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL
Entrez ID		29993	11252
HPRD ID		05936	05390
Ensembl ID		ENSG00000124507	ENSG00000100266
Uniprot IDs		Q5TZC3 Q9BY11	Q6FIA3 Q9UNF0
PDB IDs		3HAH 3HAI 3Q84 3QNI	3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?
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