PACSIN1 and TRPV4

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PACSIN1	TRPV4
Description		protein kinase C and casein kinase substrate in neurons 1	transient receptor potential cation channel subfamily V member 4
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Focal Adhesion Cilium Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane
	Molecular Function	Protein Binding Phospholipid Binding Identical Protein Binding	Actin Binding Protein Kinase C Binding Ion Channel Activity Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding
	Biological Process	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Negative Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Cellular Response To Heat Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Microtubule Polymerization Multicellular Organismal Water Homeostasis Cartilage Development Involved In Endochondral Bone Morphogenesis Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol
Pathways		Clathrin-mediated endocytosis	TRP channels
Drugs			Cannabidiol Butamben Medical Cannabis Nabiximols
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC) Distal hereditary motor neuropathies (dHMN)
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 28552196)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010)
Interacting Genes		25 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1
Entrez ID		29993	59341
HPRD ID		05936	05667
Ensembl ID		ENSG00000124507	ENSG00000111199
Uniprot IDs		Q5TZC3 Q9BY11	Q9HBA0
PDB IDs		3HAH 3HAI 3Q84 3QNI	4DX1 4DX2
Enriched GO Terms of Interacting Partners?
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