PACSIN2 and PBX4

Data Source:
BioGRID (two hybrid)

		PACSIN2	PBX4
Description		protein kinase C and casein kinase substrate in neurons 2	PBX homeobox 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Nuclear Speck Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Chromatin XY Body Nucleus
	Molecular Function	Transporter Activity Protein Binding Phospholipid Binding Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Membrane Organization Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation	Eye Development Regulation Of Transcription By RNA Polymerase II Brain Development Animal Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Embryonic Organ Development Neuron Development
Pathways		Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Prostate cancer (SNP x SNP interaction) ( 22219177)	Attention deficit hyperactivity disorder symptom score ( 27663945) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 20686565) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) LDL cholesterol ( 18193044 19060906 20686565) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 27863252) Obesity-related traits ( 23251661) Perceived unattractiveness to mosquitoes ( 28199695) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia ( 25056061 29483656 23974872) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Total cholesterol levels ( 30275531) Triglyceride levels (parental genotype effect) ( 30255771) Triglyceride levels in response to fenofibrate treatment (parental genotype effect) ( 30255771) Triglycerides ( 18193044 19060906 20686565)
Interacting Genes		16 interacting genes: COBL DNM1 FASLG GSC2 MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	65 interacting genes: ARHGEF3 BCL6 BFSP2 C14orf119 C1orf109 CCM2L CDKN2C CHCHD2 CLCNKA CPNE7 EIF1AD EIF3B EIF3F EXOC8 GADD45GIP1 GEM GINS4 GPANK1 HOXB2 HOXB5 HOXC5 HOXC8 HOXD4 HSBP1L1 IFT20 IPO13 KDM1A KLHL38 LMO2 MAGOHB MAPK9 MBD3 MEIS2 MIPOL1 NCK2 NEK6 NUTF2 OSTF1 PACSIN2 PICK1 PIH1D2 PIK3R3 PKNOX1 PKNOX2 PPL RANBP3 RBX1 RIPPLY1 RIPPLY2 SCNM1 SERTAD1 SMARCD1 SPANXN2 SPANXN3 SPG21 TFIP11 TRIM41 TSEN15 TSSK3 TXNDC9 UBTFL1 USHBP1 USP20 WWOX ZNF330
Entrez ID		11252	80714
HPRD ID		05390	16287
Ensembl ID		ENSG00000100266	ENSG00000105717
Uniprot IDs		Q6FIA3 Q9UNF0	Q9BYU1
PDB IDs		3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?
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