PACSIN2 and PACSIN3

Data Source:
HPRD (in vitro, two hybrid)

		PACSIN2	PACSIN3
Description		protein kinase C and casein kinase substrate in neurons 2	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Nuclear Speck Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	Transporter Activity Protein Binding Phospholipid Binding Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Membrane Organization Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Prostate cancer (SNP x SNP interaction) ( 22219177)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		16 interacting genes: COBL DNM1 FASLG GSC2 MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	23 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		11252	29763
HPRD ID		05390	05937
Ensembl ID		ENSG00000100266	ENSG00000165912
Uniprot IDs		Q6FIA3 Q9UNF0	Q9UKS6
PDB IDs		3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?
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