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GSK3A and PRKCG
Data Source:
HPRD
(in vitro, in vivo)
GSK3A
PRKCG
Description
glycogen synthase kinase 3 alpha
protein kinase C gamma
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Microtubule
Axon
Beta-catenin Destruction Complex
Neuronal Cell Body
Apical Dendrite
Postsynapse
Proximal Dendrite
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Postsynaptic Density
Dendrite
Calyx Of Held
Perinuclear Region Of Cytoplasm
Synaptic Membrane
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Kinase A Catalytic Subunit Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Biological Process
Regulation Of Systemic Arterial Blood Pressure
Cardiac Left Ventricle Morphogenesis
Glycogen Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Protein Phosphorylation
Signal Transduction
Dopamine Receptor Signaling Pathway
Nervous System Development
Aging
Insulin Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of UDP-glucose Catabolic Process
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of TOR Signaling
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Interleukin-3
IRE1-mediated Unfolded Protein Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Hypermethylation Of CpG Island
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Heart Contraction
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Excitatory Postsynaptic Potential
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Lithium Ion
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Amyloid-beta Formation
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Glycogen Synthase Activity, Transferring Glucose-1-phosphate
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Dendrite Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Glycogen (starch) Synthase Activity
Protein Phosphorylation
Chemical Synaptic Transmission
Learning Or Memory
Chemosensory Behavior
Phosphorylation
Peptidyl-serine Phosphorylation
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Regulation Of Response To Food
Positive Regulation Of Mismatch Repair
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Regulation Of Circadian Rhythm
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Protein Autophosphorylation
Response To Pain
Rhythmic Process
Regulation Of Phagocytosis
Innervation
Presynaptic Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Proteasomal Protein Catabolic Process
Response To Psychosocial Stress
Regulation Of Synaptic Vesicle Exocytosis
Pathways
AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
Suppression of apoptosis
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+
Drugs
Fostamatinib
Tamoxifen
Fostamatinib
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Meat-related diet (
32066663
)
Interacting Genes
34 interacting genes:
AKT1
BCL2L1
BCL3
BICD1
CREB1
CREM
DEAF1
EBNA1BP2
EIF2B5
FAM193B
GLI3
GSKIP
HSF1
LRSAM1
MAPT
MCL1
MYC
NBR1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
PRKCH
PRKCZ
PRKD3
PRKDC
PXN
RICTOR
SGK1
SGK3
SPG21
STAT2
YWHAG
64 interacting genes:
AFAP1
ANXA7
APP
ARHGEF25
ARHGEF7
CASR
CCHCR1
CD5
CDC42
CHAT
CTNNB1
CYTH2
DAB2
DDX58
DNAJC5
DVL2
EIF4E
EPHB1
EXOC5
FBXO7
GABRA1
GABRA4
GFAP
GJA1
GJA3
GRIA4
GRIN1
GRIN2B
GRIN2D
GRK2
GRM5
GSK3A
HABP4
HSPA4
IRS1
ITGB2
MAPT
MARK4
NOXA1
NRGN
NUMB
PA2G4
PARD3
PARD6A
PARD6B
PDLIM5
PEBP1
PICK1
PNMA1
PPP1R14A
RANBP10
RGS2
SCN3A
SDC2
SMURF1
STXBP1
TIAM1
TOP2A
TRIM5
UBE2T
VTN
YWHAB
YWHAE
YWHAG
Entrez ID
2931
5582
HPRD ID
06002
01502
Ensembl ID
ENSG00000105723
ENSG00000126583
Uniprot IDs
A0A024R0L5
P49840
B2R5T1
B7Z3W6
P05129
PDB IDs
2DFM
2E73
2UZP
Enriched GO Terms of Interacting Partners
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