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PRKCG and GABRA1
Data Source:
HPRD
(in vivo)
PRKCG
GABRA1
Description
protein kinase C gamma
gamma-aminobutyric acid type A receptor subunit alpha1
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Postsynaptic Density
Dendrite
Calyx Of Held
Perinuclear Region Of Cytoplasm
Synaptic Membrane
Presynaptic Cytosol
Postsynaptic Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cytoplasmic Vesicle Membrane
Dendrite Membrane
Chloride Channel Complex
Neuron Projection
Synapse
Postsynaptic Membrane
Postsynapse
GABA Receptor Complex
GABA-A Receptor Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
GABA-A Receptor Activity
Inhibitory Extracellular Ligand-gated Ion Channel Activity
Chloride Channel Activity
Drug Binding
Benzodiazepine Receptor Activity
GABA Receptor Activity
GABA-gated Chloride Ion Channel Activity
Neurotransmitter Receptor Activity
Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Biological Process
Protein Phosphorylation
Chemical Synaptic Transmission
Learning Or Memory
Chemosensory Behavior
Phosphorylation
Peptidyl-serine Phosphorylation
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Regulation Of Response To Food
Positive Regulation Of Mismatch Repair
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Regulation Of Circadian Rhythm
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Protein Autophosphorylation
Response To Pain
Rhythmic Process
Regulation Of Phagocytosis
Innervation
Presynaptic Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Proteasomal Protein Catabolic Process
Response To Psychosocial Stress
Regulation Of Synaptic Vesicle Exocytosis
Signal Transduction
Gamma-aminobutyric Acid Signaling Pathway
Chemical Synaptic Transmission
Ion Transmembrane Transport
Regulation Of Membrane Potential
Nervous System Process
Synaptic Transmission, GABAergic
Regulation Of Postsynaptic Membrane Potential
Chloride Transmembrane Transport
Inhibitory Synapse Assembly
Pathways
Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+
Signaling by ERBB4
GABA receptor activation
GABA receptor activation
Drugs
Tamoxifen
Fostamatinib
Lorazepam
Lorazepam
Ethchlorvynol
Enflurane
Temazepam
Temazepam
Butabarbital
Butalbital
Butalbital
Phenytoin
Topiramate
Etomidate
Etomidate
Talbutal
Talbutal
Pentobarbital
Pentobarbital
Olanzapine
Clobazam
Clobazam
Meprobamate
Meprobamate
Carisoprodol
Eszopiclone
Eszopiclone
Alprazolam
Alprazolam
Secobarbital
Zolpidem
Metharbital
Metharbital
Picrotoxin
Methohexital
Chlordiazepoxide
Chlordiazepoxide
Amoxapine
Amoxapine
Adinazolam
Adinazolam
Lamotrigine
Lamotrigine
Thiopental
Medroxyprogesterone acetate
Clorazepic acid
Clorazepic acid
Acamprosate
Midazolam
Midazolam
Flurazepam
Flurazepam
Isoflurane
Isoflurane
Primidone
Primidone
Halazepam
Halazepam
Propofol
Diazepam
Diazepam
Progabide
Oxazepam
Oxazepam
Methylphenobarbital
Triazolam
Triazolam
Ethanol
Zaleplon
Methoxyflurane
Methoxyflurane
Memantine
Clonazepam
Clonazepam
Methyprylon
Methyprylon
Thiamylal
Halothane
Halothane
Phenobarbital
Desflurane
Zopiclone
Flumazenil
Flumazenil
Estazolam
Estazolam
Sevoflurane
Sevoflurane
Dihydroquinidine barbiturate
Quinidine barbiturate
Amobarbital
Aprobarbital
Butobarbital
Heptabarbital
Hexobarbital
Ginkgo biloba
Glutethimide
Glutethimide
Barbital
Camazepam
Camazepam
Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione
Delorazepam
Delorazepam
Flunitrazepam
Flunitrazepam
Ethyl loflazepate
Ethyl loflazepate
Cloxazolam
Cloxazolam
Bromazepam
Bromazepam
Clotiazepam
Clotiazepam
Fludiazepam
Ketazolam
Ketazolam
Prazepam
Prazepam
Quazepam
Quazepam
Cinolazepam
Cinolazepam
Nitrazepam
Nitrazepam
Prasterone
Taurine
Ganaxolone
Clomethiazole
Adipiplon
Brotizolam
Brotizolam
Stiripentol
Etizolam
Etizolam
Thiocolchicoside
Brexanolone
Apalutamide
Remimazolam
Remimazolam
Muscimol
Benzodiazepine
Benzodiazepine
Pinazepam
Pinazepam
Medazepam
Medazepam
Loprazolam
Loprazolam
Doxefazepam
Doxefazepam
Lormetazepam
Lormetazepam
5,7,2′-trihydroxy-6,8-dimethoxyflavone
Nordazepam
Nordazepam
Oxazepam acetate
Oxazepam acetate
Cinazepam
Cinazepam
Bentazepam
Bentazepam
Mexazolam
Mexazolam
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Gait speed in old age (
28077804
)
Interacting Genes
64 interacting genes:
AFAP1
ANXA7
APP
ARHGEF25
ARHGEF7
CASR
CCHCR1
CD5
CDC42
CHAT
CTNNB1
CYTH2
DAB2
DDX58
DNAJC5
DVL2
EIF4E
EPHB1
EXOC5
FBXO7
GABRA1
GABRA4
GFAP
GJA1
GJA3
GRIA4
GRIN1
GRIN2B
GRIN2D
GRK2
GRM5
GSK3A
HABP4
HSPA4
IRS1
ITGB2
MAPT
MARK4
NOXA1
NRGN
NUMB
PA2G4
PARD3
PARD6A
PARD6B
PDLIM5
PEBP1
PICK1
PNMA1
PPP1R14A
RANBP10
RGS2
SCN3A
SDC2
SMURF1
STXBP1
TIAM1
TOP2A
TRIM5
UBE2T
VTN
YWHAB
YWHAE
YWHAG
5 interacting genes:
DRD4
PPP3CA
PRKCD
PRKCG
UBQLN1
Entrez ID
5582
2554
HPRD ID
01502
00662
Ensembl ID
ENSG00000126583
ENSG00000022355
Uniprot IDs
B2R5T1
B7Z3W6
P05129
A8K177
P14867
PDB IDs
2E73
2UZP
6CDU
6D1S
6D6T
6D6U
6HUG
6HUJ
6HUK
6HUO
6HUP
6I53
6X3S
6X3T
6X3U
6X3V
6X3W
6X3X
6X3Z
6X40
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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