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PRKCG and NUMB
Data Source:
HPRD
(in vitro)
PRKCG
NUMB
Description
protein kinase C gamma
NUMB endocytic adaptor protein
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Postsynaptic Density
Dendrite
Calyx Of Held
Perinuclear Region Of Cytoplasm
Synaptic Membrane
Presynaptic Cytosol
Postsynaptic Cytosol
Nucleus
Cytoplasm
Early Endosome
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endosome Membrane
Basolateral Plasma Membrane
Extrinsic Component Of Plasma Membrane
Clathrin-coated Vesicle
Apical Part Of Cell
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Protein Binding
Beta-catenin Binding
Alpha-catenin Binding
Cadherin Binding
Biological Process
Protein Phosphorylation
Chemical Synaptic Transmission
Learning Or Memory
Chemosensory Behavior
Phosphorylation
Peptidyl-serine Phosphorylation
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Regulation Of Response To Food
Positive Regulation Of Mismatch Repair
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Regulation Of Circadian Rhythm
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Protein Autophosphorylation
Response To Pain
Rhythmic Process
Regulation Of Phagocytosis
Innervation
Presynaptic Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Proteasomal Protein Catabolic Process
Response To Psychosocial Stress
Regulation Of Synaptic Vesicle Exocytosis
Axonogenesis
Lateral Ventricle Development
Neuroblast Division In Subventricular Zone
Positive Regulation Of Cell Migration
Adherens Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+
Activated NOTCH1 Transmits Signal to the Nucleus
Recycling pathway of L1
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Drugs
Tamoxifen
Fostamatinib
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Coronary artery calcification (
17903303
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Multisite chronic pain (
31194737
)
Interacting Genes
64 interacting genes:
AFAP1
ANXA7
APP
ARHGEF25
ARHGEF7
CASR
CCHCR1
CD5
CDC42
CHAT
CTNNB1
CYTH2
DAB2
DDX58
DNAJC5
DVL2
EIF4E
EPHB1
EXOC5
FBXO7
GABRA1
GABRA4
GFAP
GJA1
GJA3
GRIA4
GRIN1
GRIN2B
GRIN2D
GRK2
GRM5
GSK3A
HABP4
HSPA4
IRS1
ITGB2
MAPT
MARK4
NOXA1
NRGN
NUMB
PA2G4
PARD3
PARD6A
PARD6B
PDLIM5
PEBP1
PICK1
PNMA1
PPP1R14A
RANBP10
RGS2
SCN3A
SDC2
SMURF1
STXBP1
TIAM1
TOP2A
TRIM5
UBE2T
VTN
YWHAB
YWHAE
YWHAG
37 interacting genes:
AP2A1
AP2A2
APP
DNAJC5
DPYSL2
EAF1
EGFR
EPS15
FBXO7
FRS3
IRS1
ITCH
ITGB2
ITGB3
ITGB5
L1CAM
LNX1
LNX2
MAPK8IP2
MDM2
NEDD4
NOTCH1
OLIG1
PALS1
PDZK1IP1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCZ
PTEN
RPL3
SIAH1
SPANXN2
TERF2
Entrez ID
5582
8650
HPRD ID
01502
04767
Ensembl ID
ENSG00000126583
ENSG00000133961
Uniprot IDs
B2R5T1
B7Z3W6
P05129
A0A024R681
A0A024R684
A0A024R6C4
A0A024R6F4
P49757
PDB IDs
2E73
2UZP
5NJJ
5NJK
Enriched GO Terms of Interacting Partners
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