GSK3A and STAT2

Data Source:
BioGRID (enzymatic study)

		GSK3A	STAT2
Description		glycogen synthase kinase 3 alpha	signal transducer and activator of transcription 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite	Chromatin Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Signal Transduction Dopamine Receptor Signaling Pathway Nervous System Development Aging Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interleukin-3 IRE1-mediated Unfolded Protein Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Hypermethylation Of CpG Island Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lithium Ion Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Amyloid-beta Formation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Glycogen Synthase Activity, Transferring Glucose-1-phosphate Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Viral Process Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Mitochondrial Fission
Pathways		AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		Fostamatinib
Diseases
GWAS		Meat-related diet ( 32066663)	Axial length ( 24144296) Height ( 20881960 25429064 23456168) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: AKT1 BCL2L1 BCL3 BICD1 CREB1 CREM DEAF1 EBNA1BP2 EIF2B5 FAM193B GLI3 GSKIP HSF1 LRSAM1 MAPT MCL1 MYC NBR1 PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PXN RICTOR SGK1 SGK3 SPG21 STAT2 YWHAG	22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		2931	6773
HPRD ID		06002	02778
Ensembl ID		ENSG00000105723	ENSG00000170581
Uniprot IDs		A0A024R0L5 P49840	P52630 R9QE65
PDB IDs		2DFM	2KA4 6UX2 6WCZ
Enriched GO Terms of Interacting Partners?
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