Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CXCL2 and CCL21
Data Source:
BioGRID
(pull down)
CXCL2
CCL21
Description
C-X-C motif chemokine ligand 2
C-C motif chemokine ligand 21
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Molecular Function
Protein Binding
Chemokine Activity
CXCR Chemokine Receptor Binding
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Biological Process
Response To Molecule Of Bacterial Origin
Chemotaxis
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Neutrophil Chemotaxis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Establishment Of T Cell Polarity
Immunological Synapse Formation
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Ruffle Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Response To Prostaglandin E
Mesangial Cell-matrix Adhesion
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Chemokine
Positive Regulation Of Cell Motility
Positive Regulation Of T Cell Migration
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Basophil percentage of white cells (
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
23128233
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
29403010
32888494
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
29403010
32888494
27863252
21738479
)
White blood cell types (
21738478
)
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Rheumatoid arthritis (
30423114
18794853
30572963
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Interacting Genes
19 interacting genes:
CCL11
CCL21
CCL28
CCL5
CCL8
CXCL11
CXCL12
CXCL14
CXCL5
CXCL6
CXCL9
CXCR1
CXCR2
EPS8
PF4
PIK3R1
PLG
XCL1
XCL2
32 interacting genes:
ACKR2
ACKR4
C3orf52
CCL13
CCL17
CCL23
CCL24
CCL26
CCL28
CCL5
CCR7
CTSD
CXCL10
CXCL11
CXCL12
CXCL13
CXCL14
CXCL17
CXCL2
CXCL9
GOT2
IGFBP7
LRRK1
OTP
PF4
PF4V1
PPBP
TMEM107
UBQLN4
VCAN
XCL1
XCL2
Entrez ID
2920
6366
HPRD ID
00741
04113
Ensembl ID
ENSG00000081041
ENSG00000137077
Uniprot IDs
A0A024RDD9
P19875
O00585
PDB IDs
1QNK
5OB5
2L4N
5EKI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?