Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
GRB7 and SHC1
Data Source:
HPRD
(in vivo, in vitro)
GRB7
SHC1
Description
growth factor receptor bound protein 7
SHC adaptor protein 1
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Stress Granule
Cell Projection
Mitochondrial Matrix
Cytosol
Plasma Membrane
Shc-EGFR Complex
Molecular Function
RNA Binding
Protein Binding
Protein Kinase Binding
Phosphatidylinositol Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Biological Process
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Negative Regulation Of Translation
Positive Regulation Of Cell Migration
Stress Granule Assembly
ERBB2 Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Leukocyte Migration
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Ras Protein Signal Transduction
Axon Guidance
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Reorganization
Interleukin-15-mediated Signaling Pathway
IRE1-mediated Unfolded Protein Response
Fc-epsilon Receptor Signaling Pathway
Interleukin-2-mediated Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of Growth
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Ras Protein Signal Transduction
Leukocyte Migration
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cell-cell Adhesion
Pathways
GRB7 events in ERBB2 signaling
Signaling by SCF-KIT
Downstream signal transduction
Tie2 Signaling
RET signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Asthma (
31619474
28461288
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Crohn's disease (
28067908
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
)
Ulcerative colitis (
28067908
20228799
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil counts (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Interacting Genes
54 interacting genes:
A1BG
AGAP1
AR
ATP5F1B
CALM1
CAV1
CPNE6
CREBRF
DOCK7
DYNC1I1
EGFR
ERBB2
ERBB3
ERBB4
FAM124B
FCHO1
FGB
FLAD1
GIGYF1
GIGYF2
GNB2
GRB2
HADHB
INSR
KCTD6
KIT
KMT2B
LAX1
LY6G6F
MAP3K14
MET
MSH2
PDGFRB
PDHB
PHAX
PICK1
PKM
PTK2
RET
RND1
RPS2
SETDB1
SHC1
STAC3
TCF12
TEK
TGM5
TLE1
TMSB4X
TRIM36
TRIM43
USP2
ZBTB16
ZNHIT1
143 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
Entrez ID
2886
6464
HPRD ID
03311
02780
Ensembl ID
ENSG00000141738
ENSG00000160691
Uniprot IDs
A0A0S2Z4F6
Q14451
P29353
PDB IDs
1MW4
1WGR
2L4K
2QMS
3PQZ
4WWQ
4X6S
5D0J
5EEL
5EEQ
5TYI
5U06
5U1Q
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?