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GRB7 and MSH2
Data Source:
BioGRID
(two hybrid)
GRB7
MSH2
Description
growth factor receptor bound protein 7
mutS homolog 2
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Stress Granule
Cell Projection
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Membrane
Mismatch Repair Complex
MutSalpha Complex
MutSbeta Complex
Molecular Function
RNA Binding
Protein Binding
Protein Kinase Binding
Phosphatidylinositol Binding
Identical Protein Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Double-strand/single-strand DNA Junction Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
ATPase Activity
Centromeric DNA Binding
Enzyme Binding
Protein Kinase Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
Biological Process
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Negative Regulation Of Translation
Positive Regulation Of Cell Migration
Stress Granule Assembly
ERBB2 Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Leukocyte Migration
In Utero Embryonic Development
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
Oxidative Phosphorylation
DNA Repair
Mismatch Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Cell Cycle Arrest
Germ Cell Development
Determination Of Adult Lifespan
Male Gonad Development
Response To X-ray
Response To UV-B
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
B Cell Mediated Immunity
B Cell Differentiation
Intra-S DNA Damage Checkpoint
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Positive Regulation Of Helicase Activity
Protein Localization To Chromatin
Pathways
GRB7 events in ERBB2 signaling
Signaling by SCF-KIT
Downstream signal transduction
Tie2 Signaling
RET signaling
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Ovarian cancer
GWAS
Asthma (
31619474
28461288
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Crohn's disease (
28067908
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
)
Ulcerative colitis (
28067908
20228799
)
Electroencephalogram traits (
25387704
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
54 interacting genes:
A1BG
AGAP1
AR
ATP5F1B
CALM1
CAV1
CPNE6
CREBRF
DOCK7
DYNC1I1
EGFR
ERBB2
ERBB3
ERBB4
FAM124B
FCHO1
FGB
FLAD1
GIGYF1
GIGYF2
GNB2
GRB2
HADHB
INSR
KCTD6
KIT
KMT2B
LAX1
LY6G6F
MAP3K14
MET
MSH2
PDGFRB
PDHB
PHAX
PICK1
PKM
PTK2
RET
RND1
RPS2
SETDB1
SHC1
STAC3
TCF12
TEK
TGM5
TLE1
TMSB4X
TRIM36
TRIM43
USP2
ZBTB16
ZNHIT1
48 interacting genes:
AKT1
ANXA7
APPBP2
ATR
BARD1
BRCA1
CCDC180
CDC14B
CDC42
CDKN1A
CHEK2
CREBBP
DVL1
EPHA2
ESR1
ESR2
EXO1
FBP1
FBP2
FGFR4
GALNT12
GRB7
HDAC6
HRAS
HUS1
LEF1
MAX
MSH3
MSH6
MYC
PCNA
PPP3R2
RAD1
RAD9A
RPA4
RPP14
SMAD1
SMC1A
SMN1
STX17
SUMO2
TDRD7
TK1
TREX1
TRIM29
USP10
XPA
ZNF510
Entrez ID
2886
4436
HPRD ID
03311
00389
Ensembl ID
ENSG00000141738
ENSG00000095002
Uniprot IDs
A0A0S2Z4F6
Q14451
A0A2R8Y6P0
P43246
PDB IDs
1MW4
1WGR
2L4K
2QMS
3PQZ
4WWQ
4X6S
5D0J
5EEL
5EEQ
5TYI
5U06
5U1Q
2O8B
2O8C
2O8D
2O8E
2O8F
3THW
3THX
3THY
3THZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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