GRB7 and PKM

Data Source:
BioGRID (two hybrid)

		GRB7	PKM
Description		growth factor receptor bound protein 7	pyruvate kinase M1/2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Pyruvate Kinase Complex Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Magnesium Ion Binding RNA Binding MRNA Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Identical Protein Binding ADP Binding Cadherin Binding Thyroid Hormone Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly ERBB2 Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Leukocyte Migration	Response To Hypoxia Liver Development Glycolytic Process ATP Biosynthetic Process Response To Nutrient Response To Gravity Programmed Cell Death Response To Muscle Inactivity Animal Organ Regeneration Cellular Response To Insulin Stimulus Pyruvate Biosynthetic Process Neutrophil Degranulation Skeletal Muscle Tissue Regeneration Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation
Pathways		GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling	Neutrophil degranulation
Drugs			Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Copper Artenimol
Diseases
GWAS		Asthma ( 31619474 28461288) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 20228799)
Interacting Genes		54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1	55 interacting genes: ANXA7 APP ARAF AURKB CCR4 CDC25A CDK4 CDKN1A CTNNB1 DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 GRB7 HERC1 HIF1A HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MDM2 MYL2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 SUMO1 SUMO2 TERF1 TINF2 TK1 TRIM35 TRIM55 TRIM63 UCHL5 YWHAQ
Entrez ID		2886	5315
HPRD ID		03311	01529
Ensembl ID		ENSG00000141738	ENSG00000067225
Uniprot IDs		A0A0S2Z4F6 Q14451	A0A024R5Z9 B4DNK4 P14618 V9HWB8
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6
Enriched GO Terms of Interacting Partners?
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