GRB7 and HADHB

Data Source:
BioGRID (two hybrid)

		GRB7	HADHB
Description		growth factor receptor bound protein 7	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Mitochondrial Nucleoid
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Acetyl-CoA C-acyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Acetyl-CoA C-myristoyltransferase Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly ERBB2 Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Leukocyte Migration	Fatty Acid Beta-oxidation Cardiolipin Acyl-chain Remodeling
Pathways		GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling	Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs
Diseases
GWAS		Asthma ( 31619474 28461288) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 20228799)
Interacting Genes		54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1	15 interacting genes: ANXA7 APP CDC42 CDKN1A CHCHD4 COX17 GRB7 HSD17B10 HSPB2 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K
Entrez ID		2886	3032
HPRD ID		03311	00887
Ensembl ID		ENSG00000141738	ENSG00000138029
Uniprot IDs		A0A0S2Z4F6 Q14451	F5GZQ3 P55084
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q	5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?
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